¿Existen ensayos clinicos disponibles sobre el coronavirus?
(Are there any clinical trials available for the coronavirus)
Primeras 5 respuestas:
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cancer clinical trials.
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Many of these drugs are now being experimentally repurposed for COVID-19 or are undergoing clinical trials in humans (4) .
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The first clinical trial of COVID-19 was registered on 23 January 2020 [4] .
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a strong response from the research community has been observed with the proliferation of independent clinical trials assessing diagnostic methods, therapeutic and prophylactic strategies.
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A total of 49 clinical trial protocols of TCM for COVID-19 were included.
cancer clinical trials.
... The coronavirus disease 2019 (COVID-19) pandemic has disrupted all aspects of clinical care, including cancer clinical trials. In March 2020, ASCO launched a survey of clinical programs represented on its Cancer Research Committee ...
Ref: Early Impact of COVID-19 on the Conduct of Oncology Clinical Trials and Long-Term Opportunities for Transformation: Findings From an American Society of Clinical Oncology Survey [JCO Oncol Pract, 2020]Many of these drugs are now being experimentally repurposed for COVID-19 or are undergoing clinical trials in humans (4) .
... against SARS-CoV-2 in vitro, in animal models, or in compassionate use trials (2, 3) . Many of these drugs are now being experimentally repurposed for COVID-19 or are undergoing clinical trials in humans (4) . Such candidates include nitazoxanide, remdesivir, favipiravir, lopinavir, darunavir, hydroxychloroquine, chloroquine, and ivermectin amongst others (5) ...
Ref: Missing clinical trial data: the knowledge gap in the safety of potential COVID-19 drugs [JCO Oncol Pract, 2020-06-03]The first clinical trial of COVID-19 was registered on 23 January 2020 [4] .
... The first clinical trial of COVID-19 was registered on 23 January 2020 [4] . Since then, an increasing number of clinical trials of COVID-19 have been registered using regimens based on traditional Chinese medicine (TCM) and Western medicine (WM). Previously, we found several problems ...
Ref: Core Outcome Set for Clinical Trials of COVID-19 based on Traditional Chinese and Western Medicine [JCO Oncol Pract, 2020-03-27]a strong response from the research community has been observed with the proliferation of independent clinical trials assessing diagnostic methods, therapeutic and prophylactic strategies.
... Since the coronavirus disease 2019 (COVID-19) outbreak was identified in December 2019 in Wuhan, China, a strong response from the research community has been observed with the proliferation of independent clinical trials assessing diagnostic methods, therapeutic and prophylactic strategies. While there is no intervention for the prevention or treatment of COVID-19 with proven clinical ...
Ref: A living systematic review protocol for COVID-19 clinical trial registrations [Wellcome Open Res, 2020-04-02]A total of 49 clinical trial protocols of TCM for COVID-19 were included.
... type of design, sponsor, patient, sample size, intervention, and evaluation index. Descriptive analysis was conducted. A total of 49 clinical trial protocols of TCM for COVID-19 were included. Primary sponsors were mainly hospitals or universities in places like Hubei, Beijing, Zhejiang and other ...
Ref: [Analysis on clinical study protocols of traditional Chinese medicine for coronavirus disease 2019]. [Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2020-03-01]As of April 21, 2020, well over 500 clinical trials have been registered at the various international and national clinical trial registry sites.
... and safety of clinical candidate interventions to treat COVID-19 are emerging at an unprecedented rate. As of April 21, 2020, well over 500 clinical trials have been registered at the various international and national clinical trial registry sites. Findings from randomised clinical trials that have been published as of April 21, 2020, have ...
Ref: A real-time dashboard of clinical trials for COVID-19 [Lancet Digit Health, 2020-04-24]A total of 78 clinical trial protocols on COVID-19 were included and 259 outcomes were collected.
... searched to retrieve clinical trial protocols and outcomes in order to form an outcome pool. A total of 78 clinical trial protocols on COVID-19 were included and 259 outcomes were collected. After standardization, 132 outcomes were identified within seven different categories, of which 58 were selected ...
Ref: Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID) [Lancet Digit Health, 2020]The number of registered trials related to COVID-19 is increasing by the day.
... address the devastating clinical and public health effects of the Coronavirus disease 2019 (COVID-19) pandemic. The number of registered trials related to COVID-19 is increasing by the day. OBJECTIVES: To describe the characteristics of the currently registered clinical trials related to COVID-19. METHODS: ...
Ref: A large number of COVID-19 interventional clinical trials were registered soon after the pandemic onset: a descriptive analysis [J. clin. epidemiol, 2020]Disorderly and intensive clinical trials of COVID-19 using traditional Chinese medicine and Western medicine are ongoing or will be carried out in China.
... Disorderly and intensive clinical trials of COVID-19 using traditional Chinese medicine and Western medicine are ongoing or will be carried out in China. However, based on the poor quality and small sample size and long completion period, we will not be able to obtain reliable, high-quality clinical evidence about COVID-19 treatment for quite ...
Ref: Systematic Review of the Registered Clinical Trials of Coronavirus Disease 2019 (COVID-19) [J. clin. epidemiol, 2020-03-03]Numerous clinical trials have been registered since the onset of the COVID-19 pandemic.
... (interquartile range 40-200). Major categories of interventions that are currently being investigated are discussed. CONCLUSIONS: Numerous clinical trials have been registered since the onset of the COVID-19 pandemic. Summarized data on these trials will assist physicians and researchers to promote patient care and ...
Ref: Review of trials currently testing treatment and prevention of COVID-19 [Clin. microbiol. infect, 2020]Most tobacco-focused clinical trials are based on locally-conducted studies that face significant challenges to implementation and successful execution.
... Most tobacco-focused clinical trials are based on locally-conducted studies that face significant challenges to implementation and successful execution. These challenges include the need for large, diverse, yet still representative study samples. This often means a protracted, costly, and inefficient recruitment process. Multi-site clinical trials can overcome some of ...
Ref: Remote Methods for Conducting Tobacco-Focused Clinical Trials. [Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020-06-12]The coronavirus disease 2019 (COVID-19) pandemic has disrupted all aspects of clinical care, including cancer clinical trials.
... The coronavirus disease 2019 (COVID-19) pandemic has disrupted all aspects of clinical care, including cancer clinical trials. In March 2020, ASCO launched a survey of clinical programs represented on its Cancer Research Committee and Research Community Forum Steering Group and taskforces to learn about the types of ...
Ref: Early Impact of COVID-19 on the Conduct of Oncology Clinical Trials and Long-Term Opportunities for Transformation: Findings From an American Society of Clinical Oncology Survey [JCO Oncol Pract, 2020]A total of 249 clinical trials were identified between January to March 15, 2020.
... and March 15, 2020. Interventional studies at different phases under the COVID-19 pipeline were included. A total of 249 clinical trials were identified between January to March 15, 2020. After filtering observational studies (194 studies), a total of 56 interventional trials were considered. The ...
Ref: Vaccines and Drug Therapeutics to Lock Down Novel Coronavirus Disease 2019 (COVID-19): A Systematic Review of Clinical Trials [Cureus, 2020-05-28]There are several randomised clinical trials of masks and respirators, but most used clinical endpoints or tested only for influenza.
... of human coronaviruses are similar, thought to be by droplet, contact and sometimes airborne routes. There are several randomised clinical trials of masks and respirators, but most used clinical endpoints or tested only for influenza. In four trials which we conducted, we tested for human coronaviruses, but only composite viral ...
Ref: Human Coronavirus Data from Four Clinical Trials of Masks and Respirators [Int. j. infect. dis, 2020]We conducted an exploratory trial with 3 arms involving hospitalized adult patients with COVID-19.
... acid were evaluated for their antiviral activity against SARS-CoV-2 in vitro before the trial initiation. We conducted an exploratory trial with 3 arms involving hospitalized adult patients with COVID-19. Patients were randomized assigned in a 1:1:1 ratio into baloxavir marboxil group, favipiravir group, and ...
Ref: Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: an Exploratory Randomized, Controlled Trial [Int. j. infect. dis, 2020-05-05]There are few phase 3 randomized double-blind placebo controlled trials on the way to investigate the safety and efficacy of remdesivir.
... no published studies that substantiate its activity in vivo until the time of this review. There are few phase 3 randomized double-blind placebo controlled trials on the way to investigate the safety and efficacy of remdesivir. Of which, one completed double blind, placebo controlled trial showed that remdesivir showed faster time ...
Ref: Available Evidence and Ongoing Clinical Trials of Remdesivir: Could It Be a Promising Therapeutic Option for COVID-19? [Front Pharmacol, 2020-05-26]We identified 412 clinical trials registers addressing the effect of pharmacological treatments on COVID-19 ( Figure 1 ),
... We identified 412 clinical trials registers addressing the effect of pharmacological treatments on COVID-19 ( Figure 1 ), which were conducted in 40 countries, predominantly from Asia and Europe (42.2% and 31.1% of clinical trials registers, respectively), being China (26.5%), USA (13.6%), Iran (10.0%) and Spain (8.7%) the ...
Ref: The race to find a SARS-CoV-2 drug can only be won by a few chosen drugs: a systematic review of registers of clinical trials of drugs aimed at preventing or treating COVID-19 [Front Pharmacol, 2020-05-09]A total of 75 registered clinical trials (63 interventional studies and 12 observational studies) of COVID-19 were obtained.
... based on inclusion and exclusion criteria, extracted data and evaluated the risk of bias. Results: A total of 75 registered clinical trials (63 interventional studies and 12 observational studies) of COVID-19 were obtained. A majority of clinical trials were sponsored by Chinese hospitals. Only 11 trials have begun ...
Ref: Systematic Review of the Registered Clinical Trials of Coronavirus Disease 2019 (COVID-19) [Front Pharmacol, 2020-03-03]Multiple intervention based clinical studies against SARS-CoV-2 are being performed throughout the world with a high concentration of clinical trials in the developed world.
... clinical studies. Hydroxychloroquine is the most common drug being tested with 83 ongoing studies. Conclusion Multiple intervention based clinical studies against SARS-CoV-2 are being performed throughout the world with a high concentration of clinical trials in the developed world. There is a high concern that most of the studies maybe repetitive; elderly and patients ...
Ref: Mechanistic rationale of drugs, Primary endpoints, Geographical distribution of clinical trials against Severe acute respiratory syndrome-related coronavirus-2: A Systematic Review [Front Pharmacol, 2020-05-26]There are currently seven completed clinical trials and 29 registered clinical trials focusing on HCQ or CQ as a therapeutic avenue for COVID-19.
... preprint trials, risk of bias was assessed using Cochrane Risk of Bias Tool 2.0. RESULTS: There are currently seven completed clinical trials and 29 registered clinical trials focusing on HCQ or CQ as a therapeutic avenue for COVID-19. Of these, five of seven trials have shown favorable outcomes for patients using CQ or ...
Ref: A Rapid Systematic Review of Clinical Trials Utilizing Chloroquine and Hydroxychloroquine as a Treatment for COVID-19 [Acad Emerg Med, 2020]48 clinical trials were identified,
... the treatment of COVID-19 at the clinicaltrials gov database on April 2, 2020 In total, 48 clinical trials were identified, and of these, 41 trials adopted drug intervention and the other 7 trials utilized biological ...
Ref: Major ongoing clinical trials for COVID-19 treatment and studies currently being conducted or scheduled in Japan [Global Health & Medicine, 2020]Clinical trial recruitment was temporary halted in many centres to reduce patients and healthcare workers’ potential exposure to the virus.
... The COVID-19 pandemic affected many activities in the healthcare system including oncology drug development. Clinical trial recruitment was temporary halted in many centres to reduce patients and healthcare workers’ potential exposure to the virus. Conversely, to continue offering treatments for patients already on effective therapies, multiple actions were timely put ...
Ref: Oncology clinical trials during the COVID-19 outbreak: lessons learnt during the crisis and future opportunities [Cancer Treat Rev, 2020-06-10]Several ongoing clinical trials are evaluating the prophylactic and therapeutic role of HCQ in COVID-19.
... clinical efficacy of HCQ in preventing COVID-19 [54] . Similar views were published in other journals [55, 56] . Several ongoing clinical trials are evaluating the prophylactic and therapeutic role of HCQ in COVID-19. The results, including the interim ones, of these trials are awaited. ...
Ref: An Updated Systematic Review of the Therapeutic Role of Hydroxychloroquine in Coronavirus Disease-19 (COVID-19) [Clin Drug Investig, 2020-05-28]COVID-19 Surveillance has delivered a trebling of virology sites to 293 (target 300),
... practices and the number in the network has doubled since February 2020 to over 1,150. COVID-19 Surveillance has delivered a trebling of virology sites to 293 (target 300), helping collect the largest ever weekly total of surveillance swabs in the UK as well ...
Ref: Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Rapid innovation to deliver extended COVID-19 surveillance and trial platforms [Clin Drug Investig, 2020]Zhang and his colleagues have made a cross-sectional survey of currently registered clinical trials concerning 2019-nCoV, including the published literature.
... Zhang et al. published in the recent issue of the Journal of Medical Virology1 . Zhang and his colleagues have made a cross-sectional survey of currently registered clinical trials concerning 2019-nCoV, including the published literature. As such, they have given a preliminary assessment on the prospects of therapy for 2019-nCoV. ...
Ref: Comments on Zhang et al: Clinical trial analysis of 2019‐nCoV therapy registered in China [J Med Virol, 2020-04-15]The several ongoing clinical trials on SARS-CoV-2 vaccines do not fall within the scope of this article.
... progress, which demands a harmonized approach of the scientific community. This article aims to provide a critical overview of the clinical trials exploring candidate drugs for potential treatment for COVID-19. The several ongoing clinical trials on SARS-CoV-2 vaccines do not fall within the scope of this article. ...
Ref: COVID‐19Clinical trials: quality matters more than quantity [Allergy, 2020-05-20]A total of 220 registered trials were evaluated as of February 27, 2020.
... each study, the registration information, study design, and administrator information are collected and summarized. RESULTS: A total of 220 registered trials were evaluated as of February 27, 2020. Hospital-initiated trials were the majority and account for 80% of the sample. Among the trials, ...
Ref: An evidence mapping and analysis of registered COVID-19 clinical trials in China [BMC Med, 2020]A recent trial of hospitalized COVID-19 patients in Brazil was stopped early (n=81) due to safety concerns.
... chloroquine poisoning have raised concerns regarding the safety of hydroxychloroquine, but scientific details are lacking. A recent trial of hospitalized COVID-19 patients in Brazil was stopped early (n=81) due to safety concerns. Patients receiving high dose chloroquine (12 grams over 10 days) had prolonged QTc (> 500 ...
Ref: Post-exposure Prophylaxis or Preemptive Therapy for SARS-Coronavirus-2: Study Protocol for a Pragmatic Randomized Controlled Trial [BMC Med, 2020-05-06]A clinical trial involving sarilumab for the treatment of severe COVID-19 is ongoing,
... the treatment of rheumatoid arthritis. These IL-6 blockers bind to soluble and membrane-bound IL-6 receptors. A clinical trial involving sarilumab for the treatment of severe COVID-19 is ongoing, where the efficacy and safety of sarilumab 200 mg and 400 mg dose administered intravenously ...
Ref: Treatment Considerations for COVID-19: A Critical Review of the Evidence (or Lack Thereof) [Mayo Clin Proc, 2020-04-30]The first anti-viral clinical trial with Lopinavir/Ritonavir has already reached the targeted sample size of 160 cases.
... been registered, anti-viral and anti-inflammatory or immunomodulation treatment are of great interest to the investigators. The first anti-viral clinical trial with Lopinavir/Ritonavir has already reached the targeted sample size of 160 cases. The data on the outcome of the treatment are currently being analyzed and re-sults are ...
Ref: Clinical trials for the treatment of Coronavirus disease 2019 (COVID-19): A rapid response to urgent need [Sci China Life Sci, 2020-02-29]a series of clinical trials with IL-6 inhibitors like tocilizumab, sarilumab and siltuximab are underway.
... of cytokine dysregulation in serious COVID-19 and interleukin (IL)-6 being the key driver of this hyperinflammation, which can cause multi-organ failure, a series of clinical trials with IL-6 inhibitors like tocilizumab, sarilumab and siltuximab are underway. Some preliminary evidence is available for their clinical efficacy. ...
Ref: IL-6 Inhibitors in the Treatment of Serious COVID-19: A Promising Therapy? [Pharmaceut Med, 2020-06-13]The eligibility criteria for each trial were reviewed for inclusion/exclusion of pregnant women.
... We conducted a search of international trial registries for trials relating to the novel coronavirus. The eligibility criteria for each trial were reviewed for inclusion/exclusion of pregnant women. Relevant data were extracted and descriptive statistics were calculated for individual and combined data. The ...
Ref: Exclusion of Pregnant Women from Clinical Trials during the Coronavirus Disease 2019 Pandemic: A Review of International Registries. [American journal of perinatology, 2020-05-19]Overall, 201 clinical trials were registered for testing the therapeutic benefits of 92 drugs or plasma, including 64 in monotherapy and 28 different combinations.
... by two reviewers. MAIN OUTCOME(S): Trial intervention, sponsorship, critical design elements and specified outcomes RESULTS: Overall, 201 clinical trials were registered for testing the therapeutic benefits of 92 drugs or plasma, including 64 in monotherapy and 28 different combinations. Only eight (8.7%) products or combinations involved new molecular entities. The other test therapies had ...
Ref: Characteristics of registered clinical trials assessing treatments for COVID-19: a cross-sectional analysis [BMJ Open, 2020-06-09]Deviations will occur in clinical trials as a result of limited resources,
... when appropriate, and choosing regimens which require less frequent visits and which are less immunosuppressive. Deviations will occur in clinical trials as a result of limited resources, and it is important to understand regulatory obligations to trial sponsors as well as to ...
Ref: Anti-cancer therapy and clinical trial considerations for gynecologic oncology patients during the COVID-19 pandemic crisis [Gynecol. oncol, 2020]Thirty-four clinical trials were for TCM therapy and 63 clinical trials were for WM therapy.
... study protocols were excluded. Finally, 97 eligible study protocols were included from ChiCTR and ClinicalTrials.gov. Thirty-four clinical trials were for TCM therapy and 63 clinical trials were for WM therapy. All clinical trials will be conducted in China. These clinical trials comprised 75 RCTs (53 ...
Ref: Core Outcome Set for Clinical Trials of COVID-19 Based on Traditional Chinese and Western Medicine [Front Pharmacol, 2020-05-25]antiviral drugs, antimalarial drugs, glucocorticoids, plasma therapy, virus vaccine, and other Western drugs,
... diagnosed, China has carried out more than 100 clinical studies of new coronavirus infection, including antiviral drugs, antimalarial drugs, glucocorticoids, plasma therapy, virus vaccine, and other Western drugs, while Chinese medicine research accounted for half of the studies. Most of the trials were ...
Ref: Clinical trial analysis of 2019‐nCoV therapy registered in China [J Med Virol, 2020-03-05]There are currently ten registered trials taking place globally to investigate efficacy for COVID-19 (Table 1A : Antivirals).
... and in vivo models [12, 14] . There has been much interest in this molecule, following treatment of the first COVID-19 case, and subsequent recovery, in the USA [15] . There are currently ten registered trials taking place globally to investigate efficacy for COVID-19 (Table 1A : Antivirals). ...
Ref: Ongoing Clinical Trials for the Management of the COVID-19 Pandemic [Trends Pharmacol Sci, 2020-04-09]One of the first purportedly positive trials was published by Gautret et al [5] .
... although the scientific community is racing to find possible active agents for COVID-19 [4] . One of the first purportedly positive trials was published by Gautret et al [5] . Earlier versions were released due the urgent need to provide data to health care providers ...
Ref: How robust are the results of one of the first positive trials exploring hydroxychloroquine for treatment of COVID-19? [Trends Pharmacol Sci, 2020-05-11]Since the outbreak of COVID-19, the number of COVID-19 trials registered on various trial registry platforms worldwide has been rapidly increasing.
... COVID-19 research set by world experts and funders [7] . The sooner the clinical trials are initiated, the higher the chance that an efficacious and safe intervention can be identified. Since the outbreak of COVID-19, the number of COVID-19 trials registered on various trial registry platforms worldwide has been rapidly increasing. ...
Ref: An evidence mapping and analysis of registered COVID-19 clinical trials in China [BMC Med, 2020-06-01]For many HF clinical trials, the enrollment of new participants has been halted because these activities usually require in-person visits.
... conduct. 6. Enrollment. We expect the COVID-19 pandemic will have a negative impact on enrollment. For many HF clinical trials, the enrollment of new participants has been halted because these activities usually require in-person visits. While we endorse this approach, we encourage maintenance of the patient screening architecture for HF ...
Ref: Heart Failure Collaboratory Statement on Clinical Trials in the Landscape of COVID-19 [JACC Heart Fail, 2020-03-27]clinical trials offer patients who have failed multiple drugs access to study medications with alternative mode of action and the potential for relief from inflammation-mediated symptoms.
... for patients with inflammatory bowel disease to be recruited and maintained in clinical trials. However, clinical trials offer patients who have failed multiple drugs access to study medications with alternative mode of action and the potential for relief from inflammation-mediated symptoms. Therefore, the continuation of clinical trials in IBD during the COVID-19 pandemic is important both ...
Ref: Clinical trials for inflammatory bowel disease: a global guidance during COVID-19 pandemic [J. crohns. colitis, 2020]Results Only one clinical trial on the efficacy of antiviral therapy in management of COVID-19 was found.
... 15, 2020. Two independent researchers performed the screening, and finally the related studies were included. Results Only one clinical trial on the efficacy of antiviral therapy in management of COVID-19 was found. The results depicted that adding Lopinavir-Ritonavir to the standard treatment regimen of patients with severe ...
Ref: Antiviral therapy in management of COVID-19: a systematic review on current evidence. [Archives of academic emergency medicine, 2020]COVID-19 trials should be adequately powered to generate evidence.
... COVID-19 trials should be adequately powered to generate evidence. They need to be large and well designed. Priority should be given to interventions that reflect the specific needs of countries and are readily implementable. For resource-poor settings, that means ...
Ref: Global coalition to accelerate COVID-19 clinical research in resource-limited settings [Lancet, 2020-04-02]Numerous clinical trials are currently investigating multiple therapeutic candidates and strategies (1) , including prophylaxis (2) .
... published and scientific data collected from thousands of patients have been released. This impressive research and clinical work made it possible to better understand the disease and its different phases. Numerous clinical trials are currently investigating multiple therapeutic candidates and strategies (1) , including prophylaxis (2) . ...
Ref: Repurposed prophylaxis strategies for COVID-19: a systematic review [Lancet, 2020-06-03]Seven studies including four clinical trials and three observational studies have entered into the study.
... studies and analyzed using CMA v. 2.2.064. heterogeneity was also assessed using I-squared test. Results: Seven studies including four clinical trials and three observational studies have entered into the study. The results of meta-analysis of clinical trials showed that there were no significant differences between ...
Ref: Hydroxychloroquine Versus COVID-19: A Rapid Systematic Review and Meta-Analysis [Lancet, 2020-04-20]Many regulatory authorities from different world regions have issued guidance statements regarding the conduct of clinical trials during this COVID-19 crisis.
... affecting the integrity of the trial. The social contract with our patients demands no less. Many regulatory authorities from different world regions have issued guidance statements regarding the conduct of clinical trials during this COVID-19 crisis. However, international trials may benefit from expert guidance from a global panel of experts to ...
Ref: Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: an Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). [European heart journal, 2020-06-04]a series of clinical trials on Coronavirus Disease 2019 (COVID-19) have been registered or carried out.
... Since its outbreak in December 2019, a series of clinical trials on Coronavirus Disease 2019 (COVID-19) have been registered or carried out. However, the significant heterogeneity and less critical outcomes of such trials may be leading to a waste of research resources. This study aimed to ...
Ref: Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID) [European heart journal, 2020]We have around 59 clinical trials and registries actives in the Unit.
... We have around 59 clinical trials and registries actives in the Unit. During this period, we have had close contact with patients, sometimes was proactive contact by the patient, and sometimes a proactive contact performed by the investigator team. The trial nurse ...
Ref: Clinical trials and Haemophilia during the COVID‐19’ pandemic: Madrid’s Experience [Haemophilia, 2020-05-16]Most promising among these efforts are randomized controlled trials (RCTs),
... across institution and country lines in an unprecedented fashion, to evaluate potential COVID-19 therapies [1]. Most promising among these efforts are randomized controlled trials (RCTs), which represent the highest level of evidence which informs clinical decision-making in the evidence-based medicine ...
Ref: Trials and tribulations: so many potential treatments, so few answers [Int Orthop, 2020-05-24]A total of 171 COVID-19-related interventional trials were identified on Feb 22nd, 2020.
... We reviewed the characteristics of interventional trials from Chinese Clinical Trial Registration (ChiCTR) and ClinicalTrials.gov. A total of 171 COVID-19-related interventional trials were identified on Feb 22nd, 2020. These trials are classified into 4 categories based on treatment modalities, including chemical drugs, biological ...
Ref: Appealing for Efficient, Well Organized Clinical Trials on COVID-19 [Int Orthop, 2020-03-07]An immediate critical reassessment of trial methodology based on clinical and scientific priorities is essential to ensure the resilience of clinical cancer research
... posed to patients with cancer by the current COVID-19 pandemic demand rapid structural changes in healthcare delivery, with many positive changes likely to continue long term. An immediate critical reassessment of trial methodology based on clinical and scientific priorities is essential to ensure the resilience of clinical cancer research and optimize patient-centered care. ...
Ref: Rethinking cancer clinical trials for COVID-19 and beyond [Nat Cancer, 2020-05-29]trying to carry out large, international trials in the midst of coronavirus lockdowns Cohen co-leads a network of HIV prevention trials,
... of North Carolina, Chapel Hill, says he and his colleagues are in a new situation: trying to carry out large, international trials in the midst of coronavirus lockdowns Cohen co-leads a network of HIV prevention trials, some of which have paused during the pandemic But for other studies, he says, “stopping ...
Ref: Clinical trials press on for conditions other than COVID-19. Will the pandemic’s effects sneak into their data? [Science, 2020]Further clinical experience was obtained through a randomized controlled trial in patients with Ebola virus disease.
... 2 increases in aspartate transaminase (AST) and alanine transaminase (ALT) (personal communication: Gilead Sciences, Inc.). Further clinical experience was obtained through a randomized controlled trial in patients with Ebola virus disease. In this trial 175 patients received intravenous remdesivir with a loading dose on day 1 ...
Ref: Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trial [Trials, 2020-05-24]COVID-19 trials should be adequately powered to generate evidence. They need to be large and well designed.
... COVID-19 trials should be adequately powered to generate evidence. They need to be large and well designed. Priority should be given to interventions that reflect the specific needs of countries and are readily implementable. For resource-poor settings, that means interventions need to be affordable and available, and ...
Ref: Global coalition to accelerate COVID-19 clinical research in resource-limited settings [Lancet, 2020-04-02]randomized controlled clinical trials (RCTs) are necessary to ensure that clinicians can treat patients effectively during this outbreak and the next.
... of efficacy of some interventions that, while receiving media coverage, lack robust evidence. Moving forward, randomized controlled clinical trials (RCTs) are necessary to ensure that clinicians can treat patients effectively during this outbreak and the next. To do so, academic medical centers must address two key research issues: (1) how to ...
Ref: COVID-19 Clinical Trial Oversight at a Major Academic Medical Center: Approach of the Michigan Medicine COVID-19 Clinical Trial Committees [Clin Infect Dis, 2020-05-11]Three registered clinical trials are planned regarding the use of favipiravir against COVID-19 (21) (22) (23) .
... in the overall population (61.21% versus 51.67%; p=0.14). However, this difference existed for a subgroup of non-critical patients without hypertension or diabetes (favipiravir 71.43% versus arbidol 55.86%, p=0.02) (20) . Three registered clinical trials are planned regarding the use of favipiravir against COVID-19 (21) (22) (23) . ...
Ref: [Comment] Treatment strategies to fight the new coronavirus SARS-CoV-2: A challenge for a Rubik's Cube solver [Exp Ther Med, 2020-04-28]We observe a clear prevalence of monocentric trials with highly heterogeneous endpoints and a significant disconnect between geographic distribution and disease prevalence,
... interventions, study endpoints and study designs. Data and analyses are publicly available at https://bioinfo.ieo.it/shiny/app/CovidCT Results. We observe a clear prevalence of monocentric trials with highly heterogeneous endpoints and a significant disconnect between geographic distribution and disease prevalence, implying that most countries would need to recruit unrealistic percentages of their total prevalent cases ...
Ref: Semantic and geographical analysis of Covid-19 trials reveals a fragmented clinical research landscape likely to impair informativeness. [Exp Ther Med, 2020-05-19]We found 218 registered trials investigating the use of hydroxychloroquine in COVID-19 patients for either treatment or prophylaxis.
... We found 218 registered trials investigating the use of hydroxychloroquine in COVID-19 patients for either treatment or prophylaxis. The majority are either in phase 3 (n=88), or phase 2 (n=52), and most are conducted in Europe (n=76). Only three of these trials had published results [29, 30, 32] ...
Ref: A large number of COVID-19 interventional clinical trials were registered soon after the pandemic onset: a descriptive analysis [J Clin Epidemiol, 2020-06-08]three clinical trials assessed the protective role of BCG vaccine against COVID-19.
... met the inclusion criteria. Specifically, seven developed vaccines for the S protein of SARS-CoV-2 and three clinical trials assessed the protective role of BCG vaccine against COVID-19. The first group included phase I/II trials with different types of molecules (DNA or mRNA ...
Ref: The vaccine journey for COVID-19: a comprehensive systematic review of current clinical trials in humans. [Panminerva medica, 2020-05-26]Most COVID-19 clinical trials are necessarily run in hospitals that treat large numbers of patients.
... be carried out whilst patients are being taken care of as a matter of urgency. Most COVID-19 clinical trials are necessarily run in hospitals that treat large numbers of patients. They require the collection of biological samples, diagnostic procedures and the collection of multiple types ...
Ref: Ethical rationale for better coordination of clinical research on COVID-19 [Res Ethics, 2020-05-28]A total of 171 COVID-19-related interventional trials were identified (138 from ChiCTR and 33 from ClinicalTrials.gov).
... A total of 171 COVID-19-related interventional trials were identified (138 from ChiCTR and 33 from ClinicalTrials.gov). The registration date distribution of these trials was shown in Figure 1 . Of the trials registered at ChiCTR, 120 were approved by the institutional review boards. The 171 trials ...
Ref: Appealing for Efficient, Well Organized Clinical Trials on COVID-19 [Res Ethics, 2020-03-07]For six trials, two units were able to ship IMPs to patients' homes or to local hospitals.
... Provision of IMPs and research devices, as well as shipment of research samples, were uniformly warranted. For six trials, two units were able to ship IMPs to patients" homes or to local hospitals. Three units provided larger amounts of trial medications to patients to minimise hospital visits. ...
Ref: Challenges in early phase clinical trials for childhood cancer during the COVID-19 pandemic: a report from the new agents group of the Spanish Society of Paediatric Haematology and Oncology (SEHOP) [Clin Transl Oncol, 2020-05-29]The COVID‐19 pandemic has halted many ongoing CNS clinical trials, especially in Alzheimer’s disease.
... The COVID‐19 pandemic has halted many ongoing CNS clinical trials, especially in Alzheimer’s disease. These long‐duration trials involve many stakeholders, especially the patients and their family members, who have demonstrated their commitment to developing new therapeutic interventions for this devastating disease. We certainly do ...
Ref: Salvaging CNS Clinical Trials halted due to COVID‐19 [CPT Pharmacometrics Syst Pharmacol, 2020-05-28]Clinical trials and other research activities are inevitably impacted.
... syndrome coronavirus-2 (SARS-CoV-2) pandemic has necessitated changes in cancer care delivery as resources are reallocated. Clinical trials and other research activities are inevitably impacted. Start-up activities for new trials may be deferred and recruitment suspended. For patients already enrolled ...
Ref: Adapting to a Pandemic - Conducting Oncology Trials during the SARS-CoV-2 Pandemic [Clin. cancer res, 2020]The purpose of this review is to quantify the landscape of current clinical trials ongoing for therapies in the treatment of COVID-19.
... PURPOSE: The purpose of this review is to quantify the landscape of current clinical trials ongoing for therapies in the treatment of COVID-19. A secondary purpose is to examine the relationship between public and scientific interests in potential therapies for COVID-19. METHODS: A systematic search of clinicaltrials.gov was undertaken on April 22, ...
Ref: Trials and tribulations: so many potential treatments, so few answers [Int. orthop, 2020]The Outcomes Related to COVID-19 treated with Hydroxychloroquine
... The Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease (ORCHID) trial is a multicenter, blinded, randomized trial of hydroxychloroquine versus placebo for the treatment of adults hospitalized with COVID-19. This document provides the rationale ...
Ref: Rationale and Design of ORCHID: A Randomized Placebo-Controlled Trial of Hydroxychloroquine for Adults Hospitalized with COVID-19 [Ann. Am. Thorac. Soc. (Online), 2020]Since the outbreak of coronavirus disease 2019 (COVID-19), hundreds of clinical trial protocols have been registered and have begun subject recruitment.
... Since the outbreak of coronavirus disease 2019 (COVID-19), hundreds of clinical trial protocols have been registered and have begun subject recruitment. By 20 February 2020, 228 protocols were already listed in two clinical trial registries www.chictr.org. cn à , àà . However, there were some deficiencies in the registered clinical trial ...
Ref: Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID) [Engineering (Beijing), 2020-03-18]The first published clinical trials evaluating antiviral activity of CQ in COVID-19 patients were from China.
... The first published clinical trials evaluating antiviral activity of CQ in COVID-19 patients were from China. Gao et al. 20 published the first study in letter format, where they enlisted "more than 100 patients" and found CQ superior to control intervention (which they do not elucidate ...
Ref: A Rapid Systematic Review of Clinical Trials Utilizing Chloroquine and Hydroxychloroquine as a Treatment for COVID‐19 [Acad Emerg Med, 2020-05-29]201 clinical trials were registered for testing the therapeutic benefits of 92 drugs or plasma, including 64 in monotherapy and 28 different combinations.
... two reviewers. MAIN OUTCOME(S): Trial intervention, sponsorship, critical design elements and specified outcomes RESULTS: Overall, 201 clinical trials were registered for testing the therapeutic benefits of 92 drugs or plasma, including 64 in monotherapy and 28 different combinations. Only eight (8.7%) products or combinations involved new molecular entities. The other test therapies had ...
Ref: Characteristics of registered clinical trials assessing treatments for COVID-19: a cross-sectional analysis [BMJ Open, 2020-06-09]The current coronavirus disease 2019 (COVID-19) pandemic has necessitated the more widespread use of telemedicine technology for clinical care,
... of major centers. These factors effectively limit patient participation, particularly for those in rural areas. The current coronavirus disease 2019 (COVID-19) pandemic has necessitated the more widespread use of telemedicine technology for clinical care, and has prompted consideration of its increased use for clinical trials. In this opinion piece, ...
Ref: Optimizing telemedicine to facilitate amyotrophic lateral sclerosis clinical trials [Muscle nerve, 2020]From now until 2023, there will have been several telling trials already made available.
... The long window to finalize this study may also have been a disincentive. From now until 2023, there will have been several telling trials already made available. It is very likely that a vaccine may have even reached the market by March 2023. Indeed, ...
Ref: COVID-19: Why SOLIDARITY and DisCoVeRy trials may fail to bring informative and timely results [Muscle nerve, 2020-06-02]Remdesivir is evaluated in 5 clinical trials but with the highest median number of planned inclusions per trial.
... SARS-CoV-2 but no clinical data has been provided yet to support this announcement. 28, 29 Remdesivir is evaluated in 5 clinical trials but with the highest median number of planned inclusions per trial. Studies in vitro in human airway epithelial cell assays demonstrated that remdesivir inhibits replication of ...
Ref: A brief review of antiviral drugs evaluated in registered clinical trials for COVID-19 [Muscle nerve, 2020-03-20]The electronic database accredited for interventional trials allows fast trial implementation for candidate therapeutic agents.
... for harmonized, scalable data collection, pathophysiological analysis, and deep phenotyping of COVID-19, which enables rapid generation of evidence for improved medical care and identification of candidate therapeutic and preventive strategies. The electronic database accredited for interventional trials allows fast trial implementation for candidate therapeutic agents. ...
Ref: Studying the pathophysiology of coronavirus disease 2019 - a protocol for the Berlin prospective COVID-19 patient cohort (Pa- COVID-19) [Muscle nerve, 2020-05-11]The only clinical trial found was performed on 199 patients with severe COVID-19, using Lopinavir-Ritonavir regimen.
The only clinical trial found was performed on 199 patients with severe COVID-19, using Lopinavir-Ritonavir regimen.
Ref: Antiviral therapy in management of COVID-19: a systematic review on current evidence [Arch Acad Emerg Med, 2020-04-06]The Right to Try Act was signed into law May 30, 2018.
... on accrual to clinical trials, even after adjusting for number of incident cancer cases. 7 The Right to Try Act was signed into law May 30, 2018. This law ensures that patients diagnosed with life-threatening diseases and who are unable to participate ...
Ref: Treating COVID‐19 in Rural America [J Rural Health, 2020-05-03]Moving forward, randomized controlled clinical trials (RCTs) are necessary to ensure that clinicians can treat patients effectively during this outbreak and the next.
... to perceptions of efficacy of some interventions that, while receiving media coverage, lack robust evidence. Moving forward, randomized controlled clinical trials (RCTs) are necessary to ensure that clinicians can treat patients effectively during this outbreak and the next. To do so, academic medical centers must address two key research issues: (1) how to ...
Ref: COVID-19 Clinical Trial Oversight at a Major Academic Medical Center: Approach of the Michigan Medicine COVID-19 Clinical Trial Committees [Clin Infect Dis, 2020-05-11]COVID-19 related research trials can be found by anyone on 10 ClinicalTrials.gov. Hubei Province of China.
... were completed. COVID-19 related research trials can be found by anyone on 10 ClinicalTrials.gov. Hubei Province of China. It spread rapidly, resulting in an epidemic throughout China, followed 6 by an increasing number of cases in other countries throughout the world. In February 2020, the 7 ...
Ref: Cardiovascular Disease Novel Coronavirus and the Search for Investigational Therapies [J Vasc Surg, 2020-05-17]The randomised controlled trials of psychological intervention on COVID-19 will be searched in the databases by 2 researchers independently.
... Chinese Scientific Journal Database, Wan fang Database, ClinicalTrials, WHO Trials, and Chinese Clinical Trial Registry. The randomised controlled trials of psychological intervention on COVID-19 will be searched in the databases by 2 researchers independently. Clinical recovery time and effective rate will be assessed as the primary outcomes. Changes of ...
Ref: Psychological intervention on COVID-19: A protocol for systematic review and meta-analysis [Medicine (Baltimore), 2020-05-22]Twenty-three trials were found in the trial registries (Table 1) .
... narrative letter, one research letter, one editorial, one expert consensus paper in Chinese, one national guideline document in Dutch and one in Italian) [3, [5] [6] [7] [8] [9] ]. Twenty-three trials were found in the trial registries (Table 1) . ...
Ref: A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 [J Crit Care, 2020-03-10]There are several randomised clinical trials of masks and respirators,
... of human coronaviruses are similar, thought to be by droplet, contact and sometimes airborne routes. There are several randomised clinical trials of masks and respirators, but most used clinical endpoints or tested only for influenza. In four trials which we ...
Ref: Human Coronavirus Data from Four Clinical Trials of Masks and Respirators [Int. j. infect. dis, 2020]Integrating clinical trials of experimental therapeutics is an increasingly recognized part of the response during infectious disease outbreaks.
... been evaluated for SARS-CoV and MERS-CoV there are no approved therapeutic agents available for coronaviruses. Integrating clinical trials of experimental therapeutics is an increasingly recognized part of the response during infectious disease outbreaks. Since the Ebola outbreak in West Africa and subsequent outbreaks in the Democratic Republic of ...
Ref: A brief review of antiviral drugs evaluated in registered clinical trials for COVID-19 [Int. j. infect. dis, 2020-03-20]Over thousand clinical trials with COVID‐19 patients are already listed in ClinicalTrials.com,
... to be in place, and meanwhile millions more could be infected, some with fatal outcome. Over thousand clinical trials with COVID‐19 patients are already listed in ClinicalTrials.com, some of them for assessing the utility of therapeutics approved for other conditions. However, clinical ...
Ref: Repurposing current therapeutics for treating COVID‐19: A vital role of prescription records data mining [Drug Dev Res, 2020-05-18]there are more than 382 studies registered in the clinical trials databases addressing COVID-19 including more than 80 randomized controlled trials.
... part of the response to this outbreak, there has been an impressive amount of research undertaken to better characterize the disease and to evaluate therapeutic options. By March 12, 2020, there are more than 382 studies registered in the clinical trials databases addressing COVID-19 including more than 80 randomized controlled trials. ...
Ref: Clinical trials for coronavirus disease 2019: What is being evaluated and what is not [Ann Thorac Med, 2020-03-20]Rapid generation of meaningful evidence for improved clinical management of COVID-19 requires harmonized phenotyping and comparable data collection in a welldefined patient population.
... Rapid generation of meaningful evidence for improved clinical management of COVID-19 requires harmonized phenotyping and comparable data collection in a welldefined patient population. Besides decade-long experience in multicentric phenotyping and clinical studies of community acquired pneumonia (CAPNETZ, PRO-GRESS, and CAPSyS) [9, 10] , Berlin has strong expertise in the areas of coronavirus biology ...
Ref: Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19) [Infection, 2020-06-13]There were 16 interventional trials and two observational studies that were enrolling patients during the A(H1N1)pdm09 pandemic period.
... 18 influenza registration records were reviewed (appendix 8). There were 16 interventional trials and two observational studies that were enrolling patients during the A(H1N1)pdm09 pandemic period. The treatments under investigation were oseltamivir, sambucol supplement, zanamivir, peramivir, amantadine, pomegranate supplement, nitazoxanide and favipiravir. 11 studies were completed, four were ...
Ref: Compassionate drug (mis)use during pandemics: lessons for COVID-19 from 2009. [Infection, 2020-05-12]Without further extensive preclinical studies, sofosbuvir has already entered clinical trials for treating COVID-19 [1] .
... test efficacy demonstrated that sofosbuvir was unable to cure any HEV patients [5] . Recent in silico molecular docking has indicated that sofosbuvir may inhibit RdRp of SARS-CoV-2 [6] . Without further extensive preclinical studies, sofosbuvir has already entered clinical trials for treating COVID-19 [1] . ...
Ref: Overwhelming COVID-19 Clinical Trials: Call for Prospective Meta-analysis [Trends Pharmacol Sci, 2020-05-20]An important part of this research has been focused on randomized controlled clinical trials to evaluate potential therapies for COVID-19.
... The COVID-19 pandemic has led to an unprecedented response in terms of clinical research activity. An important part of this research has been focused on randomized controlled clinical trials to evaluate potential therapies for COVID-19. The results from this research need to be obtained as rapidly as possible. This presents ...
Ref: Efficient adaptive designs for clinical trials of interventions for COVID-19 [Trends Pharmacol Sci, 2020-05-25]The STREAM Clinical Trial is the largest trial for MDR-TB ever conducted.
... the pandemic on clinical trials can be especially profound given their complexities and operational requirements. The STREAM Clinical Trial is the largest trial for MDR-TB ever conducted. Currently operating in seven countries, the trial had 126 participants on treatment and 312 additional ...
Ref: Challenges in Tuberculosis Clinical Trials in the Face of the COVID-19 Pandemic: A Sponsor's Perspective. [Tropical medicine and infectious disease, 2020-05-27]Many existing, effective treatments on infections with coronavirus and other RNA-virus have been proposed to test for its effectiveness on COVID-19 patients.
... Many existing, effective treatments on infections with coronavirus and other RNA-virus have been proposed to test for its effectiveness on COVID-19 patients. Given the fast-growing number of undergoing trials, 10 we expect that many papers on trials for COVID-19 patients will be published very soon. Since the sample size should be determined ...
Ref: The quality of the reported sample size calculation in clinical trials on COVID-19 patients indexed in PubMed [Eur J Intern Med, 2020-04-30]hundreds of clinical trial protocols have been registered and have begun subject recruitment.
... Since the outbreak of coronavirus disease 2019 (COVID-19), hundreds of clinical trial protocols have been registered and have begun subject recruitment. By 20 February 2020, 228 protocols were already listed in two clinical trial registries www.chictr.org. cn à , àà . However, there ...
Ref: Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID) [Engineering (Beijing), 2020-03-18]Clinical trial for COVID-19 was first registered on January 23, 2020.
... Clinical trial for COVID-19 was first registered on January 23, 2020. In the last few weeks, an escalating number of clinical trials has been planned and registered with ongoing investigations taking place. From the Chinese Clinical Trial Registry (http://www.chictr.org.cn) and U.S. ...
Ref: Clinical trials for the treatment of Coronavirus disease 2019 (COVID-19): A rapid response to urgent need [Sci China Life Sci, 2020-02-29]This cohort study investigates how the coronavirus disease 2019 (COVID-19) pandemic is associated with national enrollment in cancer clinical trials.
This cohort study investigates how the coronavirus disease 2019 (COVID-19) pandemic is associated with national enrollment in cancer clinical trials.
Ref: Association of the Coronavirus Disease 2019 (COVID-19) Outbreak With Enrollment in Cancer Clinical Trials [JAMA Netw Open, 2020-06-01]For ongoing therapeutic trials requiring imaging, a pandemic poses significant challenges.
... and PET pharmacokinetic studies are all considered non-essential during a pandemic and are largely discontinued. For ongoing therapeutic trials requiring imaging, a pandemic poses significant challenges. Unlike other adaptations to trial workflow through remote study visits, delayed site-monitoring visits and direct ...
Ref: Impact of the COVID-19 crisis on imaging in oncological trials [Eur J Nucl Med Mol Imaging, 2020-06-12]A series of approved drugs for other symptoms is currently underway in clinical trials for these patients,
... A series of approved drugs for other symptoms is currently underway in clinical trials for these patients, including Chloroquine, Hydroxychloroquine, and Remdesivir worldwide. This because, safe, timely and effective supportive treatments are the inevitable principle in patients who develop severe manifestations of COVID19. ...
Ref: Mesenchymal Stem Cell Therapy for COVID-19: Present or Future [Stem Cell Rev Rep, 2020-04-13]While there has been an increase in the number of clinical trials for prevention of infection by SARS-CoV-2
... both prevention and treatment settings, have included repurposing arms, as shown in Figure 4 . While there has been an increase in the number of clinical trials for prevention of infection by SARS-CoV-2 over period covered by this report, the proportion of trials for prevention has actually declined ...
Ref: Covid19db -- An online database of trials of medicinal products to prevent or treat COVID-19, with a specific focus on drug repurposing [Stem Cell Rev Rep, 2020-05-29]We identified 1,308 eligible registered trials.
... study design, status, phase, primary endpoints, experimental interventions, and geographic location among other qualifiers. RESULTS: We identified 1,308 eligible registered trials. The majority of trials were initially registered with ClinicalTrials.gov (n= 703; 53.7%) and the Chinese ...
Ref: A large number of COVID-19 interventional clinical trials were registered soon after the pandemic onset: a descriptive analysis [J. clin. epidemiol, 2020]Therefore, different clinical trials have been conducted to identify possible treatment options for COVID-19.
... line of scientific research aimed at developing safe and effective treatments for COVID-19 [9] . Therefore, different clinical trials have been conducted to identify possible treatment options for COVID-19. Several existing antiviral drugs, previously developed or used as treatments for severe acute respiratory syndrome ...
Ref: Anti COVID-19 Drugs: Need for More Clinical Evidence and Global Action [Adv Ther, 2020-04-29]After filtering observational studies (194 studies), a total of 56 interventional trials were considered.
... included. A total of 249 clinical trials were identified between January to March 15, 2020. After filtering observational studies (194 studies), a total of 56 interventional trials were considered. The majority of clinical trials have been conducted on chloroquine (n=10) and traditional Chinese medications ...
Ref: Vaccines and Drug Therapeutics to Lock Down Novel Coronavirus Disease 2019 (COVID-19): A Systematic Review of Clinical Trials [Cureus, 2020-05-28]a growing number of clinical trials have been registered to study their preventative potential for at-risk populations using a range of dosing schemes and outcome measures.
... COVID-19 disease has become prime candidates to be repositioned as therapeutic and preventative agents, and a growing number of clinical trials have been registered to study their preventative potential for at-risk populations using a range of dosing schemes and outcome measures. This rapid systematic review protocol aims to provide streamlined and timely synthesis on methodologies and ...
Ref: Repositioned chloroquine and hydroxychloroquine as antiviral prophylaxis for COVID-19: A protocol for rapid systematic review of randomized controlled trials [Cureus, 2020-04-23]There are currently seven completed clinical trials and 29 registered clinical trials focusing on HCQ or CQ as a therapeutic avenue for COVID‐19.
... preprint trials, risk of bias was assessed using Cochrane Risk of Bias Tool 2.0. RESULTS: There are currently seven completed clinical trials and 29 registered clinical trials focusing on HCQ or CQ as a therapeutic avenue for COVID‐19. Of these, five of seven trials have shown favorable outcomes for patients using CQ or ...
Ref: A Rapid Systematic Review of Clinical Trials Utilizing Chloroquine and Hydroxychloroquine as a Treatment for COVID‐19 [Acad Emerg Med, 2020-05-29]