¿Qué biomarcadores permiten predecir la severidad del curso clinico de la infección por 2019-nCOV

(Which biomarkers predict the severe clinical course of 2019-ncov infection?)

Primeras 5 respuestas:

A concordance index (C-index), calibration curve, decision curve and the clinical impact curve were calculated to assess the predictive accuracy.

Platelet count is a simple and readily available biomarker,

higher levels of inflammatory indicators; low levels of lymphocyte subsets, and a longer NCT.

ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury.

IP-10 and MCP-3 were excellent predictors for the progression of COVID-19,

A concordance index (C-index), calibration curve, decision curve and the clinical impact curve were calculated to assess the predictive accuracy.

... compared. Multivariate Cox regression analysis was performed to identify potential biomarkers for predicting disease progression. A concordance index (C-index), calibration curve, decision curve and the clinical impact curve were calculated to assess the predictive accuracy. Results The data showed that the white blood cell count, neutrophil count and platelet count ...

Ref: The hemocyte counts as a potential biomarker for predicting disease progression in COVID-19: a retrospective study [Clin. chem. lab. med, 2020]

Platelet count is a simple and readily available biomarker,

... Platelet count is a simple and readily available biomarker, which is independently associated with disease severity and risk of mortality in the intensive care unit (ICU) [4] [5] [6] . Moreover, a low platelet count correlates with higher disease ...

Ref: Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis [Clin Chim Acta, 2020-03-13]

higher levels of inflammatory indicators; low levels of lymphocyte subsets, and a longer NCT.

... older age; higher incidence of fever, fatigue, chest distress/breath shortness, severer disease assessment on admission; higher levels of inflammatory indicators; low levels of lymphocyte subsets, and a longer NCT. Multivariate analysis also identified NCD4LR as an independent risk factor for delayed NCT. ROC analysis ...

Ref: Neutrophil to CD4+ lymphocyte ratio as a potential biomarker in predicting virus negative conversion time in COVID-19 [Int Immunopharmacol, 2020]

ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury.

... load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, albumin (ALB), CRP, LDH, LYM ...

Ref: Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury [Sci China Life Sci, 2020]

IP-10 and MCP-3 were excellent predictors for the progression of COVID-19,

... that continuously high levels were associated with deteriorated progression of disease and fatal outcome. Furthermore, IP-10 and MCP-3 were excellent predictors for the progression of COVID-19, and the combination of the two cytokines showed the biggest area under the curve (AUC) ...

Ref: Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19 [J Allergy Clin Immunol, 2020-04-29]

Interleukins 6 (IL-6) and 10 (IL-10) and serum ferritin were strong discriminators for severe disease.

... and coagulation measures were also significantly elevated in patients with both severe and fatal COVID-19. Interleukins 6 (IL-6) and 10 (IL-10) and serum ferritin were strong discriminators for severe disease. Conclusions Several biomarkers which may potentially aid in risk stratification models for predicting severe and ...

Ref: Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. [Clinical chemistry and laboratory medicine, 2020-04-10]

Hypertension, elevated serum Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count.

... chronic systemic inflammation. A deep network analysis has suggested clinical biomarkers predicting the higher risk: Hypertension, elevated serum Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count. CONCLUSIONS: The revealed biomarkers can be applied directly in clinical practice. For newly infected patients, ...

Ref: Diabetes and metabolic syndrome as risk factors for COVID-19 [Diabetes Metab Syndr, 2020]

Most of severe cases demonstrated elevated levels of infection-related biomarkers and inflammatory cytokines.

... leukocytes counts and neutrophil-lymphocyte-ratio (NLR), as well as lower percentages of monocytes, eosinophils, and basophils. Most of severe cases demonstrated elevated levels of infection-related biomarkers and inflammatory cytokines. The number of T cells significantly decreased, and more hampered in severe cases. Both helper ...

Ref: Dysregulation of immune response in patients with COVID-19 in Wuhan, China [Clin. infect. dis, 2020]

Studies have demonstrated significantly higher levels of renal biomarkers such as serum urea, creatinine and markers of glomerular filtration rate in severe cases (35) .

Ref: cord_uid r8mn4lzv The role of biomarkers in diagnosis of COVID-1... r8mn4lzv The role of biomarkers in diagnosis of COVID-1... r8mn4lzv The role of biomarkers in diagnosis of COVID-1... Name: title, dtype: object [Clin. infect. dis, cord_uid r8mn4lzv 2020-05-13 r8mn4lzv 2020-05-13 r8mn4lzv 2020-05-13 Name: publish_time, dtype: object]

NLR, LDH, d-dimers, CRP, fibrinogen and ferritin

... retrospective nature of this study and the small number of subjects analyzed, we showed that NLR, LDH, d-dimers, CRP, fibrinogen and ferritin can be used early at the patient"s first visit for SARS-CoV 2 infection symptoms and ...

Ref: Prognosis of COVID-19: Changes in laboratory parameters. [Le infezioni in medicina, 2020-06-01]

Excessive and uncontrolled releases of pro-inflammatory cytokines

... recovered from COVID-19; however, both T cells and NK cells were reduced in severe cases. Excessive and uncontrolled releases of pro-inflammatory cytokines such as IL-1B, IL-1RA, IL-7, IL-8, IL-9, IL-10, fibroblast growth factor (FGF), granulocyte-macrophage colony-stimulating factor ...

Ref: A Precision Medicine Approach to SARS-CoV-2 Pandemic Management [Curr Treat Options Allergy, 2020]

lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP).

... selected three biomarkers that predict the survival of individual patients with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). In particular, relatively high levels of LDH alone seem to play a crucial role in ...

Ref: A machine learning-based model for survival prediction in patients with severe COVID-19 infection [Curr Treat Options Allergy, 2020-03-01]

a link between thrombocytopenia and COVID-19 severity or mortality was suggested.

... evidence of potentially useful clinical biomarkers to predict COVID-19 progression and disease outcomes. Of those, a link between thrombocytopenia and COVID-19 severity or mortality was suggested. In this opinion report, we examine the published evidence of hematological and hemostatic laboratory derangements ...

Ref: Hemostatic laboratory derangements in COVID-19 with a focus on platelet count. [Platelets, 2020-05-26]

Preliminary findings from COVID-19 studies have shown the association of biomarkers of acute cardiac injury and coagulation with worse prognosis.

... COVID-19 outbreak to identify patients with an increased risk of adverse outcomes and/or myocardial injury. Preliminary findings from COVID-19 studies have shown the association of biomarkers of acute cardiac injury and coagulation with worse prognosis. While these biomarkers are recognised for CVD, there is emerging prospect that they may aid ...

Ref: Prognostic Value of Cardiovascular Biomarkers in COVID-19: A Review [Viruses, 2020]

The neutrophil to lymphocyte ratio (NLR) has been suggested as a simple marker of the systemic inflammatory response in critical care patients.

... The neutrophil to lymphocyte ratio (NLR) has been suggested as a simple marker of the systemic inflammatory response in critical care patients. 8, 9 It has also been reported as an independent prognostic factor for noninfectious diseases, such as acute myocardial infarction, stroke, and several types of cancers. [10] [11] [12] In ...

Ref: Neutrophil to lymphocyte ratio as prognostic and predictive factor in patients with coronavirus disease 2019: A retrospective cross‐sectional study [J Med Virol, 2020-06-09]

ferritin, C-reactive protein (CRP)) correlated to IL-6 will be of increasing interest for prognostic value.

... costly cytokine analysis is not routinely performed in most laboratories, surrogate markers of infection ( ferritin, C-reactive protein (CRP)) correlated to IL-6 will be of increasing interest for prognostic value. Beyond D-dimer, prothrombin time (PT) and fibrin degradation product (FDP) [1] , there are no ...

Ref: Biomarkers associated with COVID-19 disease progression [Crit Rev Clin Lab Sci, 2020-06-05]

viral overgrowth and excess pulmonary inflammation For the former,

... the development of severe diseases has been established Pathology of severe COVID-19 has two aspects: viral overgrowth and excess pulmonary inflammation For the former, clinical trials using existing drugs such as remdesivir (nucleic acid drug), lopinavir/ritonavir combination drug (protease ...

Ref: Treatment to prevent the development of severe COVID-19 [Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020]

Inflammatory biomarkers were high (CRP 18 mg/dl) with elevated neutrophils.

... with high fever (39°C), diarrhea and onset of mild respiratory failure (PaO2/FiO2 = 230 mmHg). Inflammatory biomarkers were high (CRP 18 mg/dl) with elevated neutrophils. In the following 24 hours, the patient experienced a clinically unpredictable dramatic worsening of his ...

Ref: Machine learning in predicting respiratory failure in patients with COVID-19 pneumonia - challenges, strengths, and opportunities in a global health emergency [Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020-06-02]

cardiac troponin, renal biomarkers, lymphocytes and platelet count.

... reviewed the following biomarkers: C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, renal biomarkers, lymphocytes and platelet count. Of these, all but two, showed significantly higher levels in patients with severe complications of ...

Ref: The role of biomarkers in diagnosis of COVID-19 - A systematic review [Life Sci, 2020]

Several markers of disease severity were abnormal including absolute lymphocyte count, C-reactive protein and cardiac enzymes.

Serial laboratory and imaging tests are detailed in Table 1 . Several markers of disease severity were abnormal including absolute lymphocyte count, C-reactive protein and cardiac enzymes.

Ref: The Imperfect Cytokine Storm: Severe COVID-19 with ARDS in Patient on Durable LVAD Support [JACC Case Rep, 2020-04-08]

troponin, creatine kinase–MB fraction, myoglobin, or NT-proBNP) during COVID-19 infection.

... to March 27, 2020, to identify all observational studies that reported cardiac specific biomarkers ( troponin, creatine kinase–MB fraction, myoglobin, or NT-proBNP) during COVID-19 infection. We extracted data on patient demographics, infection severity, comorbidity history, and biomarkers during COVID-19 infection. ...

Ref: The impact of 2019 novel coronavirus on heart injury: A systemic review and Meta-analysis [Prog Cardiovasc Dis, 2020-04-16]

Heart fatty acid-binding protein, a serum biomarker for myocardial injury, is highly cardiac specific [12] [13] [14] .

... Heart fatty acid-binding protein, a serum biomarker for myocardial injury, is highly cardiac specific [12] [13] [14] . Recently, we have found that elevated HFABP levels are associated with severe COVID-19 or mild-to-severe transition features. Our study sought to determine whether the measurement of the HFABP can predict ...

Ref: Correlation between Heart fatty acid binding protein and severe COVID-19: A case-control study [PLoS One, 2020-04-29]

The elevation of cTnI and CK-MB might predict risk for death.

... The elevation of cTnI and CK-MB might predict risk for death. Notably, these single cut-off points may include a number of individuals with a normal level of myocardial markers on admission. 4 Although it is premature to say whether these patients ...

Ref: Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 [Eur Heart J, 2020-05-11]

troponin, creatine kinase-MB fraction, myoglobin, or NT-proBNP) during COVID-19 infection.

... to March 27, 2020, to identify all observational studies that reported cardiac specific biomarkers ( troponin, creatine kinase-MB fraction, myoglobin, or NT-proBNP) during COVID-19 infection. We extracted data on patient demographics, infection severity, comorbidity history, and biomarkers during COVID-19 infection. ...

Ref: The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta-analysis [Prog. cardiovasc. dis, 2020]

Levels of 14 cytokines were found to be significantly elevated in COVID-19 cases and showed different expression profiles in patients with different disease severity.

... severe, and 14 moderate patients were measured and analyzed in combination with clinical data. RESULTS: Levels of 14 cytokines were found to be significantly elevated in COVID-19 cases and showed different expression profiles in patients with different disease severity. Moreover, expression levels of IFN-Î³-induced protein 10, monocyte chemotactic protein-3, hepatocyte growth factor, monokine-induced gamma ...

Ref: Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19 [J. allergy clin. immunol, 2020]

age, sex, cTnI, CRP, PCT, and MYO.

... 22, 2020. . https://doi.org/10.1101/2020.04. 16.20068411 doi: medRxiv preprint were discharged (n=117) and patients that died (n=43). A lasso logistic regression model for COVID-19 was trained using the following as predictors: age, sex, cTnI, CRP, PCT, and MYO. ...

Ref: Clinical Decision Support Tool and Rapid Point-of-Care Platform for Determining Disease Severity in Patients with COVID-19 [medRxiv, 2020-04-22]

Fever (83.8%) and cough (70.9%) were the two most common symptoms.

... 26.8% of patients had been to Wuhan, and 73.1% had contacted with people from Wuhan. Fever (83.8%) and cough (70.9%) were the two most common symptoms. Elevated NLR and age were significantly associated with illness severity. The binary logistic analysis identified ...

Ref: The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients [Int Immunopharmacol, 2020-04-13]

Fever, cough, fatigue and shortness of breath are the predominant clinical manifestations of COVID-19,

... including at least 35,000 people in Africa as of 7 th May 2020 (1) . Fever, cough, fatigue and shortness of breath are the predominant clinical manifestations of COVID-19, with the disease taking on a severe course in 25% of individuals (2) . Advanced ...

Ref: HIV and SARS‐CoV‐2 co‐infection: A case report from Uganda [J Med Virol, 2020-05-21]

Elevated NLR and age were significantly associated with illness severity.

... with people from Wuhan. Fever (83.8%) and cough (70.9%) were the two most common symptoms. Elevated NLR and age were significantly associated with illness severity. The binary logistic analysis identified elevated NLR (hazard risk [HR] 2.46, 95% confidence interval [CI] ...

Ref: The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients [Int Immunopharmacol, 2020-04-13]

The application of glucocorticoid should be cautious in severe cases.

... patients with COVID-19 pneumonia, especially in severe cases. The level of T lymphocyte could be used as an indicator for prediction of severity and prognosis of patients with COVID-19 pneumonia. The application of glucocorticoid should be cautious in severe cases. ...

Ref: The clinical course and its correlated immune status in COVID-19 pneumonia [J Clin Virol, 2020-04-12]

The leukocytes, neutrophils, infection biomarkers [such as C-reactive protein (CRP), procalcitonin (PCT) and ferritin]

... into mild (n = 168), severe (n = 169) and critical groups (n = 52). The leukocytes, neutrophils, infection biomarkers [such as C-reactive protein (CRP), procalcitonin (PCT) and ferritin] and the concentrations of cytokines [interleukin (IL)-2R, IL-6, IL-8, IL-10 and tumor necrosis factor (TNF)-α] ...

Ref: Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19 [Clin Exp Immunol, 2020]

IL-6, IL-10 and tumor necrosis factor-α (TNF-α) were found to be markedly higher in these patients.

... presence of a pro-inflammatory cytokines storm, particularly in patients with severe and critical manifestations, as IL-6, IL-10 and tumor necrosis factor-α (TNF-α) were found to be markedly higher in these patients. IL-6 alone was even elevated in moderate cases [23] . Moreover, systemic inflammation, as well ...

Ref: Cardiovascular disease as a biomarker for an increased risk of COVID-19 infection and related poor prognosis [Biomarkers in medicine, 2020-05-19]

IFN-Î³-induced protein 10 and monocyte chemotactic protein-3 were excellent predictors for the progression of COVID-19,

... that continuously high levels were associated with deteriorated progression of disease and fatal outcome. Furthermore, IFN-Î³-induced protein 10 and monocyte chemotactic protein-3 were excellent predictors for the progression of COVID-19, and the combination of the 2 cytokines showed the biggest area under the curve of ...

Ref: Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19 [J. allergy clin. immunol, 2020]

CD3+T, CD4+T, CD8+T cells and NK cells were significantly decreased in COVID-19 patients.

... blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+T, CD4+T, CD8+T cells and NK cells were significantly decreased in COVID-19 patients. COVID-19 patients had a relatively slight decrease in CD4+T cells but a severe decrease of ...

Ref: T cell subset counts in peripheral blood can be used as discriminatory biomarkers for diagnosis and severity prediction of COVID-19 [J Infect Dis, 2020-05-07]

Lactate dehydrogenase (LDH) is one such biomarker of interest,

... are currently under investigation for their role in determination of prognosis in patients with COVID-19. Lactate dehydrogenase (LDH) is one such biomarker of interest, especially since elevated LDH levels have been associated with worse outcomes in patients with other ...

Ref: Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis [Am J Emerg Med, 2020-05-27]

blood routine, inflammatory factors, biochemical and immune-related indexes were included.

... for re-screening. Articles that provided values of laboratory indicators for severe and non-severe patients, including blood routine, inflammatory factors, biochemical and immune-related indexes were included. Pre-printed articles are also included. rticles published repeatedly, translated articles, studies did not include the ...

Ref: Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19 [Clin Chim Acta, 2020-06-06]

homocysteine and angiotensin II could play a significant role.

... to coagulation cascades in disseminated intravascular coagulation (DIC) and acute respiratory distress syndrome (ARDS). New laboratory biomarkers could be identified through the accurate analysis of multicentric case series; in particular, homocysteine and angiotensin II could play a significant role. ...

Ref: Biomarkers associated with COVID-19 disease progression [Crit Rev Clin Lab Sci, 2020]

one with elevated biomarkers consistent with acute pancreatitis the other without.

... letter we outline two cases of acute hypertriglyceridemia in patients with COVID‐19 treated with tocilizumab: one with elevated biomarkers consistent with acute pancreatitis the other without. Given the paucity of robust clinical trial data for most COVID‐19 pharmacotherapies at this time, ...

Ref: Letter to the Editor: Acute hypertriglyceridemia in patients with COVID‐19 receiving tocilizumab [J Med Virol, 2020-04-21]

c-reactive protein (CRP), procalcitonin (PCT), and lactate dehydrogenase (LDH) were frequently elevated.

... disease, creatine kinase-MB (CK-MB) was frequently elevated, with a PPE of 33%. In severe disease, c-reactive protein (CRP), procalcitonin (PCT), and lactate dehydrogenase (LDH) were frequently elevated. Based on data obtained from early COVID-19 studies, leukocyte indices in children appear inconsistent, differing ...

Ref: Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review [Clin. biochem, 2020]

The IL‐2R/lymphocyte was a prominent biomarker for early identification of severe COVID‐19 and predicting the clinical progression of the disease.

... in recovered patients, but further increased in disease‐deteriorated patients, which might be correlated with the outcome of COVID‐19. Lymphopenia and increased levels of cytokines were closely associated with disease severity. The IL‐2R/lymphocyte was a prominent biomarker for early identification of severe COVID‐19 and predicting the clinical progression of the disease. ...

Ref: Using IL‐2R/lymphocytes for predicting the clinical progression of patients with COVID‐19 [Clin Exp Immunol, 2020-05-15]

lower tumor necrosis factor-α and C-reactive protein levels,

... [11] , the mechanisms likely involve reduced overactivation of the immune system, as reflected by lower tumor necrosis factor-α and C-reactive protein levels, increased peripheral lymphocytes and CD14 + CD11c + CD11b mid regulatory dendritic cells, and disappearance ...

Ref: 2019-Novel Coronavirus-Related Acute Cardiac Injury Cannot Be Ignored [Curr Atheroscler Rep, 2020-05-07]

Patients with pneumonia had higher proportion of fever and cough and increased inflammatory biomarkers than those without pneumonia.

... and serum cytokine levels. CONCLUSION: Pediatric COVID-19 patients tended to have a mild clinical course. Patients with pneumonia had higher proportion of fever and cough and increased inflammatory biomarkers than those without pneumonia. There was no difference between allergic and non-allergic COVID-19 children in disease incidence, clinical features, ...

Ref: Clinical characteristics of 182 pediatric COVID-19 patients with different severities and allergic status [Allergy, 2020]

D-dimer is one such biomarker that has emerged as an important prognostic tool, with elevated levels in critically ill patients and those deceased.

... biomarkers which may help identify them earlier in their course of illness can be crucial. D-dimer is one such biomarker that has emerged as an important prognostic tool, with elevated levels in critically ill patients and those deceased. In this systematic review, we aimed to investigate the prognostic role of admission D-dimer levels ...

Ref: Elevated D-Dimer Levels are Associated with Increased Risk of Mortality in COVID-19: A Systematic Review and Meta-Analysis [Allergy, 2020-05-05]

The levels of C-reactive protein (CRP) in the severe group at the initial and progression stages were higher than those in the mild group.

... progressively decreased at the progression and the peak stages, but rebound in the recovery stage. The levels of C-reactive protein (CRP) in the severe group at the initial and progression stages were higher than those in the mild group. Correlation analysis showed that CRP (R = .62; P < .01), erythrocyte sedimentation rate (R ...

Ref: C-reactive protein correlates with computed tomographic findings and predicts severe COVID-19 early [J Med Virol, 2020]

high concentration of IL-1β, IFN-γ, IP-10 and MCP-1

... calcium ions also leads to injury and apoptosis of cardiomyocytes. Third, Huang"s study noted that high concentration of IL-1β, IFN-γ, IP-10 and MCP-1 could be detected in patients infected with 2019-nCoV, which might lead to activated T-helper-1 (Th1) ...

Ref: Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China [Clin Res Cardiol, 2020-03-11]

Fibrinogen, FAR, and D-dimer were higher in the severe patients, while PLTcount, Alb were much lower.

... Sensitivity, specificity, predictive values were calculated to assess the clinical value. The data showed that Fibrinogen, FAR, and D-dimer were higher in the severe patients, while PLTcount, Alb were much lower. Multivariate Cox analysis revealed that FAR and PLT count were independent risk factors for disease ...

Ref: Prediction of severe illness due to COVID-19 based on an analysis of initial Fibrinogen to Albumin Ratio and Platelet count [Platelets, 2020]

D-dimer has been consistently reported in severely ill COVID-19, the optimal cut-off level and prognostic value are not known.

... optimal doses of anticoagulation are not yet defined. Although an increase of biomarkers such as D-dimer has been consistently reported in severely ill COVID-19, the optimal cut-off level and prognostic value are not known. DISCUSSION: A number of pressing issues were identified by this review, including defining the true ...

Ref: Thrombosis risk associated with COVID-19 infection. A scoping review [Thromb Res, 2020]

serum urea, creatinine and markers of glomerular filtration rate in severe cases (35) .

Studies have demonstrated significantly higher levels of renal biomarkers such as serum urea, creatinine and markers of glomerular filtration rate in severe cases (35) .

Ref: cord_uid r8mn4lzv The role of biomarkers in diagnosis of COVID-1... r8mn4lzv The role of biomarkers in diagnosis of COVID-1... r8mn4lzv The role of biomarkers in diagnosis of COVID-1... Name: title, dtype: object [Thromb Res, cord_uid r8mn4lzv 2020-05-13 r8mn4lzv 2020-05-13 r8mn4lzv 2020-05-13 Name: publish_time, dtype: object]

There was no difference in the levels of lymphocytes and other biomarkers between the two groups (Table 1 ).

... the hospital. Meanwhile, 75 patients infected by influenza were retrospectively enrolled in our study. Compared to the SARS-COV-2 group, there were higher levels of WBC and granulocytes in influenza patients. There was no difference in the levels of lymphocytes and other biomarkers between the two groups (Table 1 ). ...

Ref: C‐reactive protein correlates with computed tomographic findings and predicts severe COVID‐19 early [J Med Virol, 2020-04-25]

IL-2R/lymphocytes, CRP and ferritin were selected as prediction markers of severe illness by multivariable logistic regression analyses.

... IL-2R/lymphocytes, CRP and ferritin were selected as prediction markers of severe illness by multivariable logistic regression analyses. These markers show that infection, injury of immunity and an exaggerated inflammatory response might exert synthetic efforts on the progression of severe illness. The performance of IL-2R/ lymphocytes exhibited higher ...

Ref: Using IL‐2R/lymphocytes for predicting the clinical progression of patients with COVID‐19 [Clin Exp Immunol, 2020-05-15]

respiratory rate, hemoglobin oxygen saturation (SaO2 ), and oxygenation indicator (PaO2 /FiO2 )1 .

... Guidelines for the diagnosis and treatment of the novel coronavirus disease 2019 (COVID-19) present clear criteria, including respiratory rate, hemoglobin oxygen saturation (SaO2 ), and oxygenation indicator (PaO2 /FiO2 )1 . This article is protected by copyright. All rights reserved. ...

Ref: Presepsin as a predictive biomarker of severity in COVID-19: a case series. [Journal of medical virology, 2020-06-12]

In severe disease, c-reactive protein (CRP), procalcitonin (PCT), and lactate dehydrogenase (LDH) were frequently elevated.

... decrease). In mild disease, creatine kinase-MB (CK-MB) was frequently elevated, with a PPE of 33%. In severe disease, c-reactive protein (CRP), procalcitonin (PCT), and lactate dehydrogenase (LDH) were frequently elevated. Based on data obtained from early COVID-19 studies, leukocyte indices in children appear inconsistent, differing ...

Ref: Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review [Clin. biochem, 2020]

severe lymphopenia and elevated levels of C-reactive protein (CRP), interleukin-6, cardiac troponin I, and D-dimer

... outcomes of COVID-19 in postoperative period would be extremely helpful. Some preliminary data suggest that severe lymphopenia and elevated levels of C-reactive protein (CRP), interleukin-6, cardiac troponin I, and D-dimer correlate with the severity of hypoxemia and may predict hospital mortality [5, 6] . Copyright ...

Ref: COVID-19 Outbreak and Surgical Practice: Unexpected Fatality in Perioperative Period [Ann Surg, 2020-03-25]

C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin,

... outcomes were included. KEY FINDINGS: Thirty-four relevant articles were identified which reviewed the following biomarkers: C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, renal biomarkers, lymphocytes and platelet count. Of these, all but two, showed significantly higher levels ...

Ref: The role of biomarkers in diagnosis of COVID-19 - A systematic review [Life Sci, 2020]

we defined cardiac injury according to cardiac biomarker troponin I level > 0.03>ug/L.

... with cardiac injury . Methods and results Data were collected from patients medical records, and we defined cardiac injury according to cardiac biomarker troponin I level > 0.03>ug/L. Among the 291 patients, 15 (5.2%) showed evidence of cardiac injury. Of 16 hospitalized patients ...

Ref: Clinical features and outcomes of 2019 novel coronavirus-infected patients with cardiac injury [Life Sci, 2020-03-16]

RNA-PCR test is still the most reliable diagnostic method, especially for asymptomatic patients.

... CONCLUSIONS The morbidity of 2019-nCoV infection in children is lower than in adults and the clinical manifestations and inflammatory biomarkers in children are nonspecific and milder than that in adults. RNA-PCR test is still the most reliable diagnostic method, especially for asymptomatic patients. ...

Ref: cord_uid yydc7ksy Clinical Analysis of 25 COVID-19 Infections in... yydc7ksy Clinical Analysis of 25 Novel Coronavirus Infe... Name: title, dtype: object [Life Sci, cord_uid yydc7ksy 2020-07-01 yydc7ksy 2020-05-12 Name: publish_time, dtype: object]

Lymphocytes and platelet count showed significantly lower levels in severe patients compared to non-severe patients.

... higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. Lymphocytes and platelet count showed significantly lower levels in severe patients compared to non-severe patients. SIGNIFICANCE: Although research is still in its early stages, the discovery of how different biomarkers ...

Ref: The role of biomarkers in diagnosis of COVID-19 - A systematic review [Life Sci, 2020]

Of those, a link between thrombocytopenia and COVID-19 severity or mortality was suggested.

... also growing evidence of potentially useful clinical biomarkers to predict COVID-19 progression and disease outcomes. Of those, a link between thrombocytopenia and COVID-19 severity or mortality was suggested. In this opinion report, we examine the published evidence of hematological and hemostatic laboratory derangements ...

Ref: Hemostatic laboratory derangements in COVID-19 with a focus on platelet count. [Platelets, 2020-05-26]

Forty-eight cytokines in the plasma samples from 50 COVID-19 cases including 11 critically ill, 25 severe, and 14 moderate patients were measured

... progression. OBJECTIVE: We sought to identify biomarkers for disease severity and progression of COVID-19. METHODS: Forty-eight cytokines in the plasma samples from 50 COVID-19 cases including 11 critically ill, 25 severe, and 14 moderate patients were measured and analyzed in combination with clinical data. RESULTS: Levels of 14 cytokines were found to ...

Ref: Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19 [J. allergy clin. immunol, 2020]

Race, age and socioeconomic status were not identified as independent predictors.

... acute renal injury (OR, 2.7; 95% CI 1.3-5.6) and initial CRP (OR,1.006; 95% CI, 1.001-1.01). Race, age and socioeconomic status were not identified as independent predictors. CONCLUSIONS Acute or pre-existing renal disease, supplemental oxygen at the time of hospitalization and initial ...

Ref: Predictors for Severe COVID-19 Infection. [Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020-05-30]

Very significantly higher number of neutrophils, monocytes, IL-8, IL-10, IL-1β and D-Dimer

... COVID-19 patients with ILD were more likely to have cough, sputum, fatigue, dyspnea, and diarrhea. Very significantly higher number of neutrophils, monocytes, IL-8, IL-10, IL-1β and D-Dimer was characterized in COVID-19 with ILD as compared to those of non-ILD COVID-19 patients. Furthermore, ...

Ref: Clinical Characteristics of COVID-19 in patients with pre-existing ILD: A retrospective study in a single center in Wuhan, China. [Journal of medical virology, 2020-06-13]

surrogate markers of infection (ferritin, C-reactive protein (CRP)) correlated to IL-6 will be of increasing interest for prognostic value.

... tocilizumab [7] . However, as costly cytokine analysis is not routinely performed in most laboratories, surrogate markers of infection (ferritin, C-reactive protein (CRP)) correlated to IL-6 will be of increasing interest for prognostic value. Beyond D-dimer, prothrombin time (PT) and fibrin degradation product (FDP) [1] , there are no ...

Ref: Biomarkers associated with COVID-19 disease progression [Crit Rev Clin Lab Sci, 2020-06-05]

elevated ACE2 (angiotensin-converting enzyme 2) expression, such as diabetes mellitus, hypertension, and cardiovascular disease.

... worse in individuals with preexisting comorbidities that involve endothelial dysfunction and may be linked to elevated ACE2 (angiotensin-converting enzyme 2) expression, such as diabetes mellitus, hypertension, and cardiovascular disease. CONCLUSIONS: Rapidly emerging data on coronavirus disease 2019, together with results from studies on severe ...

Ref: Overcoming Barriers: The Endothelium As a Linchpin of Coronavirus Disease 2019 Pathogenesis? [Arterioscler Thromb Vasc Biol, 2020]

Five biomarkers showed high accuracy for distinguishing COVID-19 patients from HC with an area under the curve (AUC) up to 0.89.

... such as Streptococcus, Rothia, Veillonella and Actinomyces, and a lower relative abundance of beneficial symbionts. Five biomarkers showed high accuracy for distinguishing COVID-19 patients from HC with an area under the curve (AUC) up to 0.89. Patients with H1N1 displayed lower diversity and different overall microbial composition compared with COVID-19 patients. ...

Ref: Alterations of the Gut Microbiota in Patients with COVID-19 or H1N1 Influenza [Clin. infect. dis, 2020]

The identification of effective laboratory biomarkers able to classify patients based on their risk is imperative in being able to guarantee prompt treatment.

... unpredictable clinical course of the disease that can rapidly develop, causing severe and deadly complications. The identification of effective laboratory biomarkers able to classify patients based on their risk is imperative in being able to guarantee prompt treatment. The analysis of recently published studies highlights the role of systemic vasculitis and cytokine mediated ...

Ref: Biomarkers associated with COVID-19 disease progression [Crit Rev Clin Lab Sci, 2020]

multiple studies have shown increased cardiac biomarkers mainly cardiac troponins I and T in the infected patients especially those with severe disease.

... is one of the important pathogenic features of COVID-19. As a surrogate for myocardial injury, multiple studies have shown increased cardiac biomarkers mainly cardiac troponins I and T in the infected patients especially those with severe disease. Myocarditis is depicted as another cause of morbidity amongst COVID-19 patients. The exact mechanisms of ...

Ref: Myocardial injury and COVID-19: Possible mechanisms [Life Sci, 2020]

IL-1b, IL-6, and TNFa

... curve log rank analysis. Results: Plasma RNLs levels were negatively correlated with inflammatory markers, including IL-1b, IL-6, and TNFa (p = 0.04, p = 0.03, p = 0.01, respectively). Patients with COVID-19 disease had ...

Ref: Decreased plasma levels of the survival factor renalase are associated with worse outcomes in COVID-19 [Life Sci, 2020-06-04]

The counts of CD8+T and CD4+T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.

... but a severe decrease of CD8+T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T cell subset counts were related to the severity and prognosis of COVID-19. The counts of CD8+T and CD4+T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity. ...

Ref: T cell subset counts in peripheral blood can be used as discriminatory biomarkers for diagnosis and severity prediction of COVID-19 [J Infect Dis, 2020-05-07]

Very significantly higher number of neutrophils, monocytes, IL-8, IL-10, IL-1ß and D-Dimer

... COVID-19 patients with ILD were more likely to have cough, sputum, fatigue, dyspnea, and diarrhea. Very significantly higher number of neutrophils, monocytes, IL-8, IL-10, IL-1ß and D-Dimer was characterized in COVID-19 with ILD as compared to those of non-ILD COVID-19 patients. Furthermore, ...

Ref: Clinical Characteristics of COVID-19 in patients with pre-existing ILD: A retrospective study in a single center in Wuhan, China [J. med. virol, 2020]

serum levels of inflammatory biomarkers (CRP, PCT, and IL6) of moderate and severe patients gradually decreased.

... in severe patients than in moderate patients on admission. With the recovery of the COVID-19, serum levels of inflammatory biomarkers (CRP, PCT, and IL6) of moderate and severe patients gradually decreased. In contrast, the counts of lymphocytes and their subsets including CD3+, CD4+, and CD8+ T ...

Ref: Characteristics of lymphocyte subsets and their predicting values for the severity of COVID-19 patients [J. med. virol, 2020-05-05]

New laboratory biomarkers could be identified through the accurate analysis of multicentric case series; in particular, homocysteine and angiotensin II could play a significant role.

... immunological (interleukin (IL)-6 and biochemical (D-dimer, troponin, creatine kinase (CK), aspartate aminotransferase (AST)), especially those related to coagulation cascades in disseminated intravascular coagulation (DIC) and acute respiratory distress syndrome (ARDS). New laboratory biomarkers could be identified through the accurate analysis of multicentric case series; in particular, homocysteine and angiotensin II could play a significant role. ...

Ref: Biomarkers associated with COVID-19 disease progression [Crit Rev Clin Lab Sci, 2020]

AST, urea, Cr, Cys-c, UA, CRP, WBC, LYM, MONO, NEU, TT, FIB, APTT, PT

... Data on AST, urea, Cr, Cys-c, UA, CRP, WBC, LYM, MONO, NEU, TT, FIB, APTT, PT levels were expressed as means ± standard deviation (SD). Differences in the levels of these parameters between the mild and severe patients of the disease were determined with ...

Ref: Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID‐19 [J Med Virol, 2020-04-10]

We aimed to examine if suPAR at baseline presentation is predictive of respiratory failure in patients presenting with symptoms of COVID-19.

... is a biomarker previously shown to be associated with adverse outcomes in acute medical patients. We aimed to examine if suPAR at baseline presentation is predictive of respiratory failure in patients presenting with symptoms of COVID-19. Furthermore, we examined demographic, clinical, and biochemical differences between SARS-CoV-2-positive and negative patients. RESULTS Among ...

Ref: Low levels of the prognostic biomarker suPAR are predictive of mild outcome in patients with symptoms of COVID-19 - a prospective cohort study [J Med Virol, 2020-06-02]

lymphocytes, CRP, PCT, ALT, AST, LDH, D-dimer, CD4 T cells and IL6,

... IL-6 (1.93-fold) and IL-10 (1.55-fold). CONCLUSIONS: Some certain laboratory inspections could predict the progress of the COVID-19 changes, especially lymphocytes, CRP, PCT, ALT, AST, LDH, D-dimer, CD4 T cells and IL6, which provide valuable signals for preventing the deterioration of the disease. ...

Ref: Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19 [Clin Chim Acta, 2020-06-06]

An increase in the severity of COVID-19 pneumonia was positively associated with lower levels of platelets and albumin (all p < 0.05).

... of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. Results: An increase in the severity of COVID-19 pneumonia was positively associated with lower levels of platelets and albumin (all p < 0.05). In the critical group, the plasma levels of albumin continued to have a significant association ...

Ref: Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19 [Clin Chim Acta, 2020]

When severe, COVID-19 is a systemic illness characterized by hyperinflammation, cytokine storm, and elevations of cardiac injury biomarkers.

... respiratory syndrome novel coronavirus produces a clinical syndrome known as 2019 novel coronavirus disease (COVID-19). When severe, COVID-19 is a systemic illness characterized by hyperinflammation, cytokine storm, and elevations of cardiac injury biomarkers. Here, we review what is known about the pathophysiology of COVID-19, its cardiovascular manifestations, and ...

Ref: COVID-19 and the Heart [Circ Res, 2020]

APACHE-II, NLR, and d-dimer levels,

... ratios of COVID-19 lung lesions on CT scans are superior to previous clinical biomarkers including APACHE-II, NLR, and d-dimer levels, and are a novel and promising predictor of COVID-19 progression to severe illness. These CT ...

Ref: CT quantification of pneumonia lesions in early days predicts progression to severe illness in a cohort of COVID-19 patients [Theranostics, 2020-04-27]

Laboratory tests, including blood routine, cytokine profiles and infection markers, were collected from 389 confirmed COVID-19 patients.

... of disease severity and predicting the clinical progression of coronavirus disease-2019 (COVID-19) is urgently needed. Laboratory tests, including blood routine, cytokine profiles and infection markers, were collected from 389 confirmed COVID-19 patients. The included patients were classified into mild (n = 168), severe (n = 169) and ...

Ref: Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19 [Clin Exp Immunol, 2020]

CRP level is able to act as a marker in indicating the severity of COVID-19.

... severity of the disease. The aim of the present study was to estimate whether the CRP level is able to act as a marker in indicating the severity of COVID-19. METHODS: Patients who complained cough or chest pain with or without fever were enrolled after ...

Ref: Plasma CRP level is positively associated with the severity of COVID-19 [Ann Clin Microbiol Antimicrob, 2020]

high cardiac troponin I

... mortality and severity in COVID-19 patients. RESULTS A meta-analysis of 17,794 patients showed patients with high cardiac troponin I (OR=5.22, 95%CI=3.73-7.31, p<0.001) and AST levels (OR=3.64, 95%CI=2.84-4.66, p<0.001) were more likely to develop adverse ...

Ref: Association of cardiac biomarkers and comorbidities with increased mortality, severity, and cardiac injury in COVID-19 patients: A meta-regression and Decision tree analysis. [Journal of medical virology, 2020-06-12]

The two biomarkers readily available in routine laboratories, blood lymphocytes and neutrophil counts,

... Therefore, this rapid and unpredictable deterioration requires timely prediction of COVID-19 refractoriness and critical illness. The two biomarkers readily available in routine laboratories, blood lymphocytes and neutrophil counts, are expected to provide an accurate clinical tool to incline reasonable medication and care because ...

Ref: NLR: A Cost-effective Nomogram to Guide Therapeutic Interventions in COVID-19 [Immunol Invest, 2020]

An established biomarker for measuring the degree of orall inflammation is activated matrix metalloproteinase 8 (aMMP8), for which saliva tests are available.

... in the mouth and throat may be helpful for identification of patients at particular risk. An established biomarker for measuring the degree of orall inflammation is activated matrix metalloproteinase 8 (aMMP8), for which saliva tests are available. From our point of view, the current recommendations for the prevention of SARS-CoV-2 associated COVID-19 ...

Ref: Why Do People With Diabetes Have a High Risk for Severe COVID-19 Disease?-A Dental Hypothesis and Possible Prevention Strategy. [Journal of diabetes science and technology, 2020-06-07]

C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio,

Ref: The role of biomarkers in diagnosis of COVID-19 - A systematic review [Life Sci, 2020]

Interleukins 6 (IL-6) and 10 (IL-10) and serum ferritin

Neutrophil/lymphocyte ratio and peak platelet/lymphocyte ratio may also have prognostic value in determining severe cases.

... system and hemostasis. Lymphopenia may be considered as a cardinal laboratory finding, with prognostic potential. Neutrophil/lymphocyte ratio and peak platelet/lymphocyte ratio may also have prognostic value in determining severe cases. During the disease course, longitudinal evaluation of lymphocyte count dynamics and inflammatory indices, including LDH, ...

Ref: Hematological findings and complications of COVID‐19 [Am J Hematol, 2020-05-23]

COVID-19 infection is associated with a coagulopathy characterized by an increase in procoagulant factors such as fibrinogen,

... very large pattern of disease severity, in particular in patients with cardiovascular comorbidities [1] . COVID-19 infection is associated with a coagulopathy characterized by an increase in procoagulant factors such as fibrinogen, together with a strong elevation of D-dimers that have been associated with a higher mortality ...

Ref: Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients [Angiogenesis, 2020-05-27]

supplemental oxygen at the time of hospitalization and initial CRP were independent predictors for the development of severe COVID-19 infections.

... age and socioeconomic status were not identified as independent predictors. CONCLUSIONS: Acute or pre-existing renal disease, supplemental oxygen at the time of hospitalization and initial CRP were independent predictors for the development of severe COVID-19 infections. Every 1 unit increase in CRP increased the risk of severe disease by 0.06%. ...

Ref: Predictors for Severe COVID-19 Infection [Clin. infect. dis, 2020]

Few parameters, such Lymphocytes count, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room.

... Infection of novel Coronavirus has been declared pandemic by the WHO and now is a world public health crisis. Laboratory activity becames essential for the timely diagnosis. Few parameters, such Lymphocytes count, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. ...

Ref: Laboratory Biomarkers Predicting COVID-19 Severity in the Emergency Room [Arch. med. res, 2020]

Longitudinal outcome data can then be combined with other epidemics and old-age health data,

... the data to discover biomarkers to better handle this and the next respiratory disease pandemic. Longitudinal outcome data can then be combined with other epidemics and old-age health data, to discover the best biomarkers to predict (i) coping with infection & inflammation and thus ...

Ref: The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging) [Ageing Res Rev, 2020]

elevated levels of infection-related biomarkers and inflammatory cytokines

... as well as lower percentages of monocytes, eosinophils, and basophils Most of severe cases demonstrated elevated levels of infection-related biomarkers and inflammatory cytokines The number of T cells significantly decreased, and more hampered in severe cases Both helper ...

Ref: Dysregulation of immune response in patients with COVID-19 in Wuhan, China ;Clinical Infectious Diseases ;Oxford Academic [Clinical Infectious Diseases, nan]

C-reactive protein 0.80 (0.70-0.89).

... the curve (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), lactate dehydrogenase 0.82 (0.71-0.93), and C-reactive protein 0.80 (0.70-0.89). CONCLUSION SARS-CoV-2 affects several patient parameters underpinning the severe impact of the infection. A low ...

Ref: Low levels of the prognostic biomarker suPAR are predictive of mild outcome in patients with symptoms of COVID-19 - a prospective cohort study [Clinical Infectious Diseases, 2020-06-02]

Acute cardiac injury, defined as significant elevation of cardiac troponins, is the most commonly reported cardiac abnormality in COVID-19.

... Respiratory illness is the dominant clinical manifestation of COVID-19; CV involvement occurs much less commonly. Acute cardiac injury, defined as significant elevation of cardiac troponins, is the most commonly reported cardiac abnormality in COVID-19. It occurs in approximately 8–12% of all patients. Direct myocardial injury due to viral involvement ...

Ref: Cardiovascular disease and COVID-19 [Diabetes Metab Syndr, 2020-03-25]

In severe cases, thrombocytopenia, acute kidney injury, acute myocardial injury, and adult respiratory distress syndrome were observed.

... after illness onset was characterized by fever, cough, dyspnea, lymphopenia, and radiological multi-lobar pulmonary infiltrates. In severe cases, thrombocytopenia, acute kidney injury, acute myocardial injury, and adult respiratory distress syndrome were observed. During week 2, in mild cases, fever, cough, and systemic symptoms began to resolve and ...

Ref: Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China [Crit Care, 2020-04-30]

viable CEPs/mL were significantly increased in Covid-19 patients compared to healthy controls (p<0.001).

... As shown in Fig. 1A -G, viable CEPs/mL were significantly increased in Covid-19 patients compared to healthy controls (p<0.001). This increase was larger than those usually observed in other neoplastic or vascular diseases (4) (5) (6) . Interestingly, the increase was observed in ...

Ref: Viable circulating endothelial cells and their progenitors are increased in Covid-19 patients [Crit Care, 2020-05-05]

Low lymphocyte count and high levels of CRP, LDH, and D-Dimer are associated with severe COVID-19.

... D-Dimer (SMD = 1.073, P value <.001), and LDH (SMD = 3.345, P value <.001). Low lymphocyte count and high levels of CRP, LDH, and D-Dimer are associated with severe COVID-19. These laboratory markers could be used as clinical indicators of worsening illness and poor prognosis ...

Ref: The Association of Lymphocyte count and levels of CRP, D-Dimer, and LDH with severe coronavirus disease 2019 (COVID-19): A Meta-Analysis [Crit Care, 2020-04-24]

The leukocytes, neutrophils, infection biomarkers [such as C-reactive protein (CRP), procalcitonin (PCT) and ferritin

... into mild (n = 168), severe (n = 169) and critical groups (n = 52). The leukocytes, neutrophils, infection biomarkers [such as C-reactive protein (CRP), procalcitonin (PCT) and ferritin ] and the concentrations of cytokines [interleukin (IL)-2R, IL-6, IL-8, IL-10 and tumor necrosis factor ...

Ref: Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19 [Clin Exp Immunol, 2020]

SAA and L are sensitive indicators in evaluating the severity and prognosis of COVID-19.

... Patient with higher initial SAA level are more likely to have poor CT imaging. CONCLUSIONS: SAA and L are sensitive indicators in evaluating the severity and prognosis of COVID-19. Monitoring dynamic changes of SAA, combined with CT imaging could be valuable in diagnosis and ...

Ref: Serum Amyloid A is a biomarker of severe Coronavirus Disease and poor prognosis [J Infect, 2020]

interleukin (IL)-6, C-reactive protein (CRP), and leukocyte counts and significantly decreased lymphocyte counts.

... the risk for ICU treatment. Patients with a severe course of COVID-19 had significantly increased interleukin (IL)-6, C-reactive protein (CRP), and leukocyte counts and significantly decreased lymphocyte counts. The radiological severity grading was significantly increased in ICU patients. Multivariate random forest modelling showed ...

Ref: Intensive Care Risk Estimation in COVID-19 Pneumonia Based on Clinical and Imaging Parameters: Experiences from the Munich Cohort [J Clin Med, 2020-05-18]

can offer prognostic value as biomarker for disease outcome and control.

... Thus, understanding the T cell-response in the context of clinical severity might serve as foundation to overcome the lack of effective anti-viral immune response in severely affected COVID-19 patients and can offer prognostic value as biomarker for disease outcome and control. ...

Ref: Reappearance of Effector T Cells Predicts Successful Recovery from COVID-19 [J Clin Med, 2020-05-15]

The maximum value of NLR, PLR, PCT, and CRP

... in Sichuan Province between January 16 and March 15 were included in the analysis (ChiCTR2000029758). The maximum value of NLR, PLR, PCT, and CRP during the first 3 days after being diagnosed as severe COVID-19 was included in the ...

Ref: Neutrophil-to-lymphocyte ratio as a predictive biomarker for moderate-severe ARDS in severe COVID-19 patients [Crit Care, 2020-06-05]