¿Qué rol tienen los corticosteroides en la covid-19?
(What is the role of corticosteroids in covid-19?)
Primeras 5 respuestas:
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The role for corticosteroids in the management of COVID-19 infection is controversial.
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The role of corticosteroids is controversial in severe COVID-19 pneumonia and associated hyper-inflammatory syndrome.
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Corticosteroid use is a mainstay of therapy for those women delivering prematurely.
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Treatment with corticosteroids for COVID-19 and ARDS (acute respiratory distress syndrome) is controversial and has generally not been recommended.
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The potential detrimental effects of steroids on the immune system to fight viral infections had always been a concern for patients on long term steroids in chronic conditions.
The role for corticosteroids in the management of COVID-19 infection is controversial.
... The role for corticosteroids in the management of COVID-19 infection is controversial. Several retrospective studies suggest a potential role for corticosteroids in the management of severe COVID-19 infection with ARDS. In a single-center retrospective analysis from Wuhan Jinyintan Hospital in China, methylprednisolone ...
Ref: Immune-related (IR)-pneumonitis during the COVID-19 pandemic: multidisciplinary recommendations for diagnosis and management [J Immunother Cancer, 2020-06-17]The role of corticosteroids is controversial in severe COVID-19 pneumonia and associated hyper-inflammatory syndrome.
... cytokine storm, resulting in acute lung injury and development of acute respiratory distress syndrome (ARDS). The role of corticosteroids is controversial in severe COVID-19 pneumonia and associated hyper-inflammatory syndrome. We reported a case series of six consecutive COVID-19 patients with severe pneumonia, ARDS and ...
Ref: Can steroids reverse the severe COVID-19 induced "cytokine storm"? [J. med. virol, 2020]Corticosteroid use is a mainstay of therapy for those women delivering prematurely.
... disease 2019 (COVID-19) pandemic is causing a necessary, rapid adjustment within the field of obstetrics. Corticosteroid use is a mainstay of therapy for those women delivering prematurely. Unfortunately, corticosteroid use has been associated with worse outcomes in COVID-19 positive patients. Given this ...
Ref: Corticosteroid Guidance for Pregnancy during COVID-19 Pandemic [Am J Perinatol, 2020-04-09]Treatment with corticosteroids for COVID-19 and ARDS (acute respiratory distress syndrome) is controversial and has generally not been recommended.
... BACKGROUND: Treatment with corticosteroids for COVID-19 and ARDS (acute respiratory distress syndrome) is controversial and has generally not been recommended. CASE PRESENTATION: A woman in her sixties was admitted to hospital after ten days of flu-like symptoms. She was confirmed as Sars-CoV-2-positive and experienced a steady decrease in oxygen ...
Ref: Pasient med alvorlig covid-19 behandlet med steroider./ Pasient med alvorlig covid-19 behandlet med steroider./ Patient with severe COVID-19 treated with corticosteroids [Tidsskr. nor. laegeforen., 2020]The potential detrimental effects of steroids on the immune system to fight viral infections had always been a concern for patients on long term steroids in chronic conditions.
... The potential detrimental effects of steroids on the immune system to fight viral infections had always been a concern for patients on long term steroids in chronic conditions. A recent warning from WHO on systemic corticosteroid use amid COVID-19 raised suspicion among public and healthcare professionals regarding the safety of steroid use during the SARS-CoV-2 pandemic. The corticosteroids ...
Ref: Use of corticosteroids in asthma and COPD patients with or without COVID-19 [Respir Med, 2020]Systemic corticosteroid has been sometimes administered to severe infectious diseases combined with the specific treatment.
... No specific and effective anti-viral treatment has been approved for COVID-19 so far. Systemic corticosteroid has been sometimes administered to severe infectious diseases combined with the specific treatment. However, as lack of the specific anti-SARS-CoV-2 drug, systemic steroid treatment has not been recommended for COVID-19. ...
Ref: cord_uid 3mxfew35 Therapeutic potential of ciclesonide inahalati... 3mxfew35 Therapeutic potential of ciclesonide inahalati... Name: title, dtype: object [Respir Med, cord_uid 3mxfew35 2020 3mxfew35 2020 Name: publish_time, dtype: object]Since corticosteroids causes immune suppression by impairing the innate immunity, their use has been largely discouraged because of the fear of worsening of viral propagation.
... Since corticosteroids causes immune suppression by impairing the innate immunity, their use has been largely discouraged because of the fear of worsening of viral propagation. However, in patients who are on long term maintenance dose of steroids, there is no increased incidence of development of severe or critical pneumonia in presence of COVID-19 [6] . ...
Ref: Role of corticosteroid in the management of COVID-19: A systemic review and a Clinician’s perspective [Diabetes Metab Syndr, 2020-06-27]Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations.
... has caused a pandemic of coronavirus disease (COVID-19) with many patients developing hypoxic respiratory failure. Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations. However, corticosteroids have undesirable effects, including longer time to viral clearance. Clinical equipoise on the ...
Ref: Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan [Acta anaesthesiol. scand, 2020]Addition of adjuvant corticosteroid therapy to standard antiviral treatment of patients with coronavirus disease (COVID-19) is common in clinical practice.
... Addition of adjuvant corticosteroid therapy to standard antiviral treatment of patients with coronavirus disease (COVID-19) is common in clinical practice. However, evidence is scarce regarding the efficacy of adjuvant corticosteroids in patients who are critically ill. We retrospectively evaluated the effects of adjuvant corticosteroid treatment on the outcome of 244 ...
Ref: Adjuvant corticosteroid therapy for critically ill patients with COVID-19 [Acta anaesthesiol. scand, 2020-04-11]The role of corticosteroids is controversial in severe COVID‐19 pneumonia and associated hyper‐inflammatory syndrome.
... by an excessive pro‐inflammatory cytokine storm, resulting in acute lung injury and development of ARDS. The role of corticosteroids is controversial in severe COVID‐19 pneumonia and associated hyper‐inflammatory syndrome. We reported a case series of six consecutive COVID‐19 patients with severe pneumonia, ARDS and ...
Ref: Can steroids reverse the severe COVID‐19 induced ‘cytokine storm’? [J Med Virol, 2020-06-12]Systemic corticosteroids always was controversy in treating viral pneumonia.
... Systemic corticosteroids always was controversy in treating viral pneumonia. A newly published meta-analysis demonstrated that corticosteroids treatment was associated with longer length of stay, higher probability of bacterial infection and mortality among patients with coronavirus pneumonia [3] . In ...
Ref: High-dose but not low-dose corticosteroids potentially delay viral shedding of patients with COVID-19 [Clin Infect Dis, 2020-06-26]no data are available about the potential role of high doses of steroids for these patients.
... of the benefit of corticosteroids for the treatment of moderate-severe coronavirus disease 2019 (COVID-19) patients, no data are available about the potential role of high doses of steroids for these patients. We evaluated the mortality, the risk of need for mechanical ventilation (MV), or death and ...
Ref: High versus standard doses of corticosteroids in severe COVID-19: a retrospective cohort study [Eur J Clin Microbiol Infect Dis, 2020-10-20]Corticosteroid (CS) injections are commonly used both in primary and secondary care in the management of chronic shoulder pain.
... Corticosteroid (CS) injections are commonly used both in primary and secondary care in the management of chronic shoulder pain. On March 11 2020, the World Health Organisation (WHO) declared the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the causative virus for COVID-19) outbreak a pandemic and global health emergency. ...
Ref: Should I use steroid injections to treat shoulder pain during the COVID-19 pandemic? [JSES Int, 2020-09-09]COVID-19 is a new infectious disease causing severe respiratory failure and death for which optimal treatment is currently unclear.
... COVID-19 is a new infectious disease causing severe respiratory failure and death for which optimal treatment is currently unclear. Many therapies have been proven to be ineffective; however, promising findings related to corticosteroid therapy have been published. Analysis of published data including in this issue suggests that therapy with ...
Ref: cord_uid qbf689u2 Steroids and COVID-19: We Need a Precision App... qbf689u2 Steroids and COVID-19: We Need a Precision App... Name: title, dtype: object [JSES Int, cord_uid qbf689u2 2020-09-16 qbf689u2 2020-09-16 Name: publish_time, dtype: object]Corticosteroids (glucocorticoids) include steroid hormones that are naturally produced in the adrenal cortex of vertebrates and their synthetic analogs.
... Corticosteroids (glucocorticoids) include steroid hormones that are naturally produced in the adrenal cortex of vertebrates and their synthetic analogs. Corticosteroids do not directly attack the viruses, rather act via anti-inflammatory and immunosuppressive properties to minimize the damage created all over the body. The anti-inflammatory activity of glucocorticoids is This ...
Ref: Corticosteroids in COVID-19: Is it Rational? A Systematic Review and Meta-Analysis [SN Compr Clin Med, 2020-10-19]Evidence to support the use of steroids in coronavirus disease 2019 (COVID-19) pneumonia is lacking.
... Evidence to support the use of steroids in coronavirus disease 2019 (COVID-19) pneumonia is lacking. We aim to determine the impact of steroid use for COVID-19 pneumonia on hospital mortality. We performed a single-center retrospective cohort study in a university hospital in Madrid, Spain, during ...
Ref: A Retrospective Controlled Cohort Study of the Impact of Glucocorticoid Treatment in SARS-CoV-2 Infection Mortality [Antimicrob Agents Chemother, 2020-08-20]the role and benefit of corticosteroids has been under debate in COVID-19-related pulmonary disease.
... failed to show any mortality benefit. Similar to the previous pandemics caused by respiratory viruses, the role and benefit of corticosteroids has been under debate in COVID-19-related pulmonary disease. In this consult, we discuss the evidence regarding the efficacy of corticosteroid use in hospitalized ...
Ref: Steroids in COVID-19: An overview [Clevel. clin. j. med, 2020]The patient was continued on 40 mg/day prednisone and started on vitamin D3 and plaquenil for COVID-19.
... The patient was continued on 40 mg/day prednisone and started on vitamin D3 and plaquenil for COVID-19. He was given single doses of ceftriaxone and flagyl to treat possible infected pancreatic necrosis. One day later, his antibiotic coverage was broadened and he was started on meropenem. The ...
Ref: High-Dose Prednisone for Treatment of Autoimmune Pancreatitis in a Patient with Coronavirus Disease 2019 (COVID-19) due to Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) [Am J Case Rep, 2020-07-21]Corticosteroid use was defined as the use of intravenous systemic corticosteroids, including hydrocortisone, methylprednisolone, and dexamethasone.
... The admission laboratory indexes were defined as the first records of laboratory indexes since admission. Corticosteroid use was defined as the use of intravenous systemic corticosteroids, including hydrocortisone, methylprednisolone, and dexamethasone. The dose of corticosteroids was converted to methylprednisolone-equivalent doses (1mg methylprednisolone = 0.1875mg dexamethasone = ...
Ref: Systemic corticosteroids and mortality in severe and critical COVID-19 patients in Wuhan, China [J Clin Endocrinol Metab, 2020-09-03]The role of steroids in reducing mortality and ventilation days in patients with ARDS is well established [4, 5] .
... The role of steroids in reducing mortality and ventilation days in patients with ARDS is well established [4, 5] . In fact, Villar and his colleagues have published the largest meta-analysis of using dexamethasone treatment for the acute respiratory distress syndrome few months back and this has shown a mortality ...
Ref: Dexamethasone for treatment of severe COVID-19, a surprise? [Cardiothorac Surg, 2020-09-24]This study illustrates the management of a patient with complex SARS-CoV-2 infection and AIP and the outcomes of corticosteroid treatment in this setting.
... necessary for a coexisting disease [5, 6] . This report describes a patient with symptomatic, complicated AIP who was receiving treatment with high dose corticosteroids and was diagnosed with COVID-19. This study illustrates the management of a patient with complex SARS-CoV-2 infection and AIP and the outcomes of corticosteroid treatment in this setting. ...
Ref: High-Dose Prednisone for Treatment of Autoimmune Pancreatitis in a Patient with Coronavirus Disease 2019 (COVID-19) due to Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) [Am J Case Rep, 2020-07-21]the availability of reliable information for clinicians and patients is paramount.
... Given the current SARS-CoV-2 (COVID-19) pandemic, the availability of reliable information for clinicians and patients is paramount. There have been a number of reports stating that non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids may exacerbate symptoms in COVID-19 patients. Therefore, this review ...
Ref: COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting? [Ecancermedicalscience, 2020-03-30]Surviving Sepsis Campaign recommends using low-dose corticosteroid in intubated COVID-19 patients with ARDS,
... groups CONCLUSIONS: Existing evidence from literature is inconclusive regarding use of steroids in COVID-19 Currently, Surviving Sepsis Campaign recommends using low-dose corticosteroid in intubated COVID-19 patients with ARDS, IDSA guidelines recommend use of steroid only in the setting of clinical trials, and National ...
Ref: Corticosteroid Treatment in Patients with Severe Covid-19 Pneumonia [Chest, 2020]Patients with COVID-19 are often treated with a corticosteroid despite the lack of clinical evidence for the efficacy of such treatment.
... Patients with COVID-19 are often treated with a corticosteroid despite the lack of clinical evidence for the efficacy of such treatment. In our study, 11 of 31 patients received corticosteroid treatment, a proportion similar to that reported by an earlier study. 6 Systematic use of corticosteroid treatment is even higher in ...
Ref: Corticosteroid treatment of patients with coronavirus disease 2019 (COVID‐19) [Med J Aust, 2020-04-08]Stress dose corticosteroids should be considered in settings of acute sickness or hospitalization.
... Stress dose corticosteroids should be considered in settings of acute sickness or hospitalization. 16 Patients and families should be aware of the risk of adrenal crisis during illness or with sudden cessation of steroid use, and they should discuss this with their health-care ...
Ref: The care of patients with Duchenne, Becker, and other muscular dystrophies in the COVID‐19 pandemic [Muscle Nerve, 2020-05-05]we might expect the possibility of reducing excessive inflammatory response by corticosteroids as well as promoting the reduction of viral loads by convalescent plasma simultaneously.
... to treat patients without causing any severe adverse effects. Also, when used with systemic corticosteroids, we might expect the possibility of reducing excessive inflammatory response by corticosteroids as well as promoting the reduction of viral loads by convalescent plasma simultaneously. Further well-designed studies are needed to demonstrate the efficacy and safety of convalescent plasma transfusion ...
Ref: Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea [J Korean Med Sci, 2020-04-06]The use of corticosteroids to modulate the inflammatory response in COVID-19 remains controversial.
... The use of corticosteroids to modulate the inflammatory response in COVID-19 remains controversial. Based on an expert consensus [12] [13] [14] , their use should be carefully weighed, according to clinical evidence: in patients already taking corticosteroids for chronic diseases, increased use should ...
Ref: Emerging therapies for COVID-19 pneumonia [Expert opinion on investigational drugs, 2020-06-01]The primary goal of using NSAIDs or steroids in their various forms is pain relief.
... advising their use. Such discussions align with patient-centered care practices and enhance trust and adherence. The primary goal of using NSAIDs or steroids in their various forms is pain relief. The early administration of these evidence-based treatments not only helps patients, but may also reduce ...
Ref: COVID‐19 and Headache Medicine: A Narrative Review of Non‐Steroidal Anti‐Inflammatory Drug (NSAID) and Corticosteroid Use [Headache, 2020-07-10]Corticosteroids are the most commonly used drug therapy to suppress cytokine storm caused by various diseases.
... patients with COVID-19 has been reported. Indirect evidence from related conditions showed benefits and harms. Corticosteroids are the most commonly used drug therapy to suppress cytokine storm caused by various diseases. Based on limited data, there was no clear benefit and potential harm from corticosteroids; corticosteroid ...
Ref: Corticosteroids: A Controversial Therapy for Coronavirus Disease 2019 [J Transl Int Med, 2020-09-25]The use of glucocorticoids in COVID-19 myocarditis is debatable.
... is focusing on the respiratory complications of COVID-19 and little is known about myocarditis management. The use of glucocorticoids in COVID-19 myocarditis is debatable. In our review, there appears to be favorable outcomes related to myocarditis treated with steroid ...
Ref: Systematic Review of COVID-19 Related Myocarditis: Insights on Management and Outcome [Cardiovasc Revasc Med, 2020-08-18]Using corticosteroids during COVID-19 infection is highly controversial.
... Using corticosteroids during COVID-19 infection is highly controversial. Chen et al. reported 19 (19%) patients treated with corticosteroids for 3-15 days and methylprednisolone (1-2 mg/kg per day) and recommend for patients with acute respiratory distress syndrome that this ...
Ref: COVID-19, chronic inflammatory rheumatic disease and anti-rheumatic treatments [Clin Rheumatol, 2020-05-29]The potential role of corticosteroids in the treatment of COVID-19infected patients is mainly limited to those with acute respiratory distress syndrome (ARDS).
... The potential role of corticosteroids in the treatment of COVID-19infected patients is mainly limited to those with acute respiratory distress syndrome (ARDS). In patients with SARS-coronavirus infection, corticosteroid use was associated with delayed viral clearance but also showed possible benefits in those with ARDS 52 . Many variants have been associated with ...
Ref: Pharmacogenomics of COVID-19 therapies [NPJ Genom Med, 2020-08-18]There are many studies supporting the use of corticosteroids in patients with coronavirus infection [3, 20, 21] .
... characteristics of COVID-19 in The use of glucocorticoids remains controversial in patients infected with COVID-19. There are many studies supporting the use of corticosteroids in patients with coronavirus infection [3, 20, 21] . However, high-dose corticosteroids may be associated with increased risks of secondary infections, long-term complications, and ...
Ref: Clinical characteristics of IgG4-RD patients infected with COVID-19 in Hubei, China [Semin Arthritis Rheum, 2020-05-16]These findings support the use of corticosteroids when necessary for treatment of coexisting conditions in COVID-19 patients.
... the patient was discharged to quarantine at home, which he completed uneventfully. CONCLUSIONS Despite the use of corticosteroids due to AIP, this high risk patient recovered from COVID-19 without complications. These findings support the use of corticosteroids when necessary for treatment of coexisting conditions in COVID-19 patients. ...
Ref: High-Dose Prednisone for Treatment of Autoimmune Pancreatitis in a Patient with Coronavirus Disease 2019 (COVID-19) due to Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) [Am J Case Rep, 2020]The use of corticosteroids should be avoided in COVID-19 pneumonia unless used for other indications,
... clinical trials (RCTs). The use of lopinavir-ritonavir did not prove beneficial in a large RCT. The use of corticosteroids should be avoided in COVID-19 pneumonia unless used for other indications, based on the suggestion of harm in patients with SARS-COV-1 and Middle Eastern Respiratory Syndrome ...
Ref: Potential specific therapies in COVID-19 [Ther Adv Respir Dis, 2020-05-21]Corticosteroids have unique advantages in inhibiting inflammatory responses and have been previously used in the treatment of SARS, MERS, and influenza.
... Corticosteroids have unique advantages in inhibiting inflammatory responses and have been previously used in the treatment of SARS, MERS, and influenza. However, its uncertain efficacy and adverse reactions make doctors hesitate to use corticosteroids in the treatment of COVID-19. Here we reviewed the application of corticosteroids in the previous infectious diseases, ...
Ref: The Application of Corticosteroids in COVID-19: A Two-edged Sword [J Transl Int Med, 2020-06-25]Use of routine systematic corticosteroids should be avoided for the treatment of COVID-19.
... ARDS, and early recognition and treatment of bacterial infections and sepsis in critically ill patients. Use of routine systematic corticosteroids should be avoided for the treatment of COVID-19. There is currently no strong evidence of efficacy of HCQ/chloroquine and remdesivir or other antivirals ...
Ref: Emerging Treatment and Prevention Strategies against COVID-19: A Brief Update [J Transl Int Med, 2020-05-16]Corticosteroids inhibit expression of the cytokines involved in the inflammatory response [7] and may improve outcomes in patients with severe ARDS [8, 9] .
... SARS-CoV-2 infection results in a cytokine storm-like syndrome that precipitates the severe clinical manifestations in COVID-19 [6] . Corticosteroids inhibit expression of the cytokines involved in the inflammatory response [7] and may improve outcomes in patients with severe ARDS [8, 9] . Consequently, there is considerable interest in using corticosteroids to treat severe COVID-19. ...
Ref: Clinical Outcomes Associated with Methylprednisolone in Mechanically Ventilated Patients with COVID-19 [Clin Infect Dis, 2020-08-09]Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19.
... Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19. Therapeutic agents, including dexamethasone, are mostly transported through the body by binding to serum albumin. Herein, we report the first structure of serum albumin in complex with dexamethasone. We show ...
Ref: Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy [bioRxiv, 2020-07-23]The role of corticosteroids in the treatment of severe acute respiratory syndrome (SARS) is controversial.
... The role of corticosteroids in the treatment of severe acute respiratory syndrome (SARS) is controversial. In Hong Kong, corticosteroids were widely used because of its reported efficacy in mainland China, 1 and because four of five initial SARS patients died with best supportive treatment alone ...
Ref: Corticosteroid treatment of severe acute respiratory syndrome in Hong Kong [Journal of Infection, 2007-01-31]A combination of oral antihistamines and topical corticosteroids could be an 9 effective treatment for this adverse event.
... to remdesivir that may help clinicians differentiate from cutaneous manifestations of 8 COVID-19 65 . A combination of oral antihistamines and topical corticosteroids could be an 9 effective treatment for this adverse event. rash is a common adverse event associated with darunavir 71-73 and should be differentiated 20 ...
Ref: Review of adverse cutaneous reactions of pharmacologic interventions for coronavirus disease 2019 (COVID-19): a guide for the dermatologist [J Am Acad Dermatol, 2020-08-07]The effect of systemic corticosteroids on clinical outcomes in patients with coronavirus disease 2019 (COVID-19) remains controversial.
... The effect of systemic corticosteroids on clinical outcomes in patients with coronavirus disease 2019 (COVID-19) remains controversial. While the use of corticosteroids raises concerns regarding delayed viral clearance, secondary infections, and long-term complications that can lead to increased mortality, corticosteroids have the potential to reduce mortality if ...
Ref: Corticosteroids as adjunctive therapy in the treatment of coronavirus disease 2019: A report of two cases and literature review [J. infect. chemother, 2020]Anti-inflammatory drugs such as corticosteroids may beneficially modulate the host inflammatory response to coronavirus disease 2019 (COVID-19) pneumonia.
... Anti-inflammatory drugs such as corticosteroids may beneficially modulate the host inflammatory response to coronavirus disease 2019 (COVID-19) pneumonia. The aim of this study was to evaluate the impact of addition of corticosteroids to the hospital protocol for treatment of suspected or confirmed COVID-19 pneumonia on rates of death ...
Ref: Corticosteroid therapy for patients with COVID-19 pneumonia: a before-after study [Int J Antimicrob Agents, 2020]Treatment with corticosteroids resulted in rapid clinical resolution.
... pain and thyroid function tests revealing hyperthyroidism together with consistent ultrasonographic evidence suggesting subacute thyroiditis. Treatment with corticosteroids resulted in rapid clinical resolution. This case illustrates that subacute thyroiditis associated with viruses such as SARS-CoV-2 should be recognised ...
Ref: Subacute thyroiditis associated with COVID-19 [BMJ Case Rep, 2020-08-25]Antenatal corticosteroid treatment consists of two injections of betamethasone given 24 hours apart to improve fetal lung maturity in preterm deliveries
... assumed that all women delivered during the gestational age in which they were given steroids. Antenatal corticosteroid treatment consists of two injections of betamethasone given 24 hours apart to improve fetal lung maturity in preterm deliveries if clinical indications were consistent with imminent delivery within 7 days. Then, women were stratified ...
Ref: Antenatal Corticosteroids for Pregnant Women at High Risk of Preterm Delivery with COVID-19 Infection: A Decision Analysis [Am J Perinatol, 2020-06-30]The impact of corticosteroid treatment on virological course of coronavirus disease 2019 (COVID-19) patients remains unclear.
... The impact of corticosteroid treatment on virological course of coronavirus disease 2019 (COVID-19) patients remains unclear. This study aimed to explore the association between corticosteroid and viral clearance in COVID-19. The clinical data of COVID-19 patients from 10 hospitals of Jiangsu, China, were retrospectively collected. Cox ...
Ref: Corticosteroid therapy is associated with the delay of SARS-CoV-2 clearance in COVID-19 patients [Eur J Pharmacol, 2020]60.3% patients were administered steroids.
... studies, 3416 patients were diagnosed with SARS, 360 patients with MERS, and 275 with COVID-19; 60.3% patients were administered steroids. The meta-analyses including all studies showed no differences overall in terms of mortality (OR 1.152, ...
Ref: Efficacy of corticosteroids in patients with sars, mers and covid-19: A systematic review and meta-analysis [J. Clin. Med., 2020]The role of corticosteroids in the early and late stages of ARDS is controversial and widely debated.
... The role of corticosteroids in the early and late stages of ARDS is controversial and widely debated. Two meta-analyses demonstrated reduced mortality, increased ventilator-free days, and accelerated resolution of disease when steroids were started several days after the onset of ARDS [87, 88] . A more recent ...
Ref: Initial emergency department mechanical ventilation strategies for COVID-19 hypoxemic respiratory failure and ARDS [Am J Emerg Med, 2020-07-04]In people with COVID-19, corticosteroids may theoretically modulate the inflammatory response and reduce the risk of developing ARDS.
... the risk of progression to a severe event and reduce the need for oral corticosteroids. In people with COVID-19, corticosteroids may theoretically modulate the inflammatory response and reduce the risk of developing ARDS. Systemic corticosteroids were widely used during previous coronavirus outbreaks (SARS and Middle East respiratory syndrome ...
Ref: Inhaled corticosteroids and COVID-19: a systematic review and clinical perspective [Eur Respir J, 2020-05-07]The aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19.
... The aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. A systematic search of the literature across nine databases was conducted from inception until 15th March 2020, following the PRISMA guidelines. Patients with a validated diagnosis of COVID-19 and using ...
Ref: Use of corticosteroids in Coronavirus disease 2019 pneumonia: A systematic review of the literature [Front. Med., 2020]Corticosteroids are common components of cancer treatment and supportive care.
... use in hospitalized patients with severe COVID-19 based on new evidence of potential benefit in noncancer patients [9] [10] [11] [12] . Corticosteroids are common components of cancer treatment and supportive care. However, their impact on cancer patients with COVID-19 ...
Ref: Oncologic Immunomodulatory Agents in Patients with Cancer and COVID-19 [Front. Med., 2020-08-12]Systemic corticosteroids have broad-spectrum actions on the immune system that may suppress the exuberant systemic inflammatory response that occurs in ARDS.
... Systemic corticosteroids have broad-spectrum actions on the immune system that may suppress the exuberant systemic inflammatory response that occurs in ARDS. Severe multi-source systemic inflammation is associated with adverse outcomes, so one may think that corticosteroids may of benefit with their broad spectrum immunosuppressive effects. However, evidence has shown that use ...
Ref: COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs [Turk J Med Sci, 2020-04-21]In their Comment about the use of corticosteroids to treat 2019 novel coronavirus (2019-nCoV) lung injury,
... In their Comment about the use of corticosteroids to treat 2019 novel coronavirus (2019-nCoV) lung injury, Clark Russell and colleagues 1 summarise the available clinical evidence on corticosteroid to treat patients with severe human coronavirus infections (severe acute respiratory syndrome [SARS] coronavirus and Middle East respiratory ...
Ref: On the use of corticosteroids for 2019-nCoV pneumonia [Lancet, 2020-02-12]Anti-inflammatory drugs such as corticosteroids may beneficially modulate the host inflammatory response to CoVID-19 pneumonia.
... BACKGROUND: Anti-inflammatory drugs such as corticosteroids may beneficially modulate the host inflammatory response to CoVID-19 pneumonia. AIMS: To evaluate the impact of addition of corticosteroids to the hospital protocol for treatment of suspected or confirmed CoVID-19 pneumonia on rates of death or intensive care unit ...
Ref: Corticosteroid therapy for patients with CoVID-19 pneumonia: a before-after study [Int J Antimicrob Agents, 2020-07-04]steroid therapy may be indicated for critical cases in specific situations.
... recommended in the World Health Organization statement for the treatment of coronavirus disease 2019 (COVID-19), steroid therapy may be indicated for critical cases in specific situations. Here, we report the successful treatment of 11 cases of severe COVID-19 pneumonia with favipiravir ...
Ref: Outcome of early-stage combination treatment with favipiravir and methylprednisolone for severe COVID-19 pneumonia: A report of 11 cases [Respiratory investigation (Online), 2020]Covid-19 is a systemic infection with significant impact on the hematopoietic system.
... Covid-19 is a systemic infection with significant impact on the hematopoietic system. On admission, 36.2% of patients present with thrombocytopenia, which is more prominent among severe vs. non-severe cases (57.7 vs. 31.6%) (8) . Thrombocytopenia is a risk factor for increased morbidity ...
Ref: Immune Thrombocytopenia in a Very Elderly Patient With Covid-19 [Front Med (Lausanne), 2020-07-10]Corticosteroids, as widely used antiinflammatory agents and immunosuppressants, play an important role in the treatment of critical illness.
... Corticosteroids, as widely used antiinflammatory agents and immunosuppressants, play an important role in the treatment of critical illness. Previous studies demonstrated that corticosteroid was used in treating coronavirus diseases, including severe acute respiratory syndrome (SARS) (Jang et al., 2004; Chen et al., 2006; Yam et al., 2007) and ...
Ref: Corticosteroid Use in the Treatment of COVID-19: A Multicenter Retrospective Study in Hunan, China [Front Pharmacol, 2020-08-12]The use of corticosteroids to treat COVID-19 remained largely uncertain until recently.
... The use of corticosteroids to treat COVID-19 remained largely uncertain until recently. Although individuals being treated with long term corticosteroid were instructed to continue with their medication, the use of corticosteroids specifically to treat COVID-19 was not recommended (193) . This was ...
Ref: The Impact of Pre-existing Comorbidities and Therapeutic Interventions on COVID-19 [Front Immunol, 2020-08-11]Corticosteroids are commonly used as adjuvant therapy for acute respiratory distress syndrome by many clinicians because of their perceived anti-inflammatory effects.
... BACKGROUND: Corticosteroids are commonly used as adjuvant therapy for acute respiratory distress syndrome by many clinicians because of their perceived anti-inflammatory effects. However, for patients with severe viral pneumonia, the corticosteroid treatment is highly controversial. OBJECTIVES: The purpose of this review is to systematically evaluate the effect and potential mechanism of ...
Ref: Corticosteroid administration for viral pneumonia: COVID-19 and beyond [Clin. microbiol. infect, 2020]corticosteroid is commonly administrated to severe patients with COVID-19.
... disease 2019 (COVID-19) reminds us of the SARS outbreak in 2003, and up to date, corticosteroid is commonly administrated to severe patients with COVID-19. Osteonecrosis of the femoral head (ONFH) is a common disabling complication among convalescent SARS patients ...
Ref: cord_uid f2tfos0k Chinese herbal Huo-Gu Formula for treatment of... f2tfos0k Chinese herbal Huo-Gu Formula for treatment of... Name: title, dtype: object [Clin. microbiol. infect, cord_uid f2tfos0k 2020 f2tfos0k 2020 Name: publish_time, dtype: object]A risk-benefit analysis should be performed for each patient on the use of steroids in cancer care.
... Currently, the official World Health Organization guidance is not to start corticosteroids, but there is no robust evidence of risk in patients with cancer and coronavirus disease 2019. A risk-benefit analysis should be performed for each patient on the use of steroids in cancer care. ...
Ref: Corticosteroids for Urological Cancer Care During Coronavirus Disease 2019. Treat or Not to Treat? [Eur Urol, 2020-04-21]corticosteroid use at the organ and cellular levels.
... on the RAAS and how it can be affected by non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroid use at the organ and cellular levels. We will then discuss the relevance of these interactions on organ-specific ACE2 expression, and provide ...
Ref: Anti-Inflammatory Drugs and the Renin-Angiotensin-Aldosterone System: Current Knowledge and Potential Effects on Early SARS-CoV-2 Infection [Virus Res, 2020]Very little direct evidence exists on use of corticosteroids in patients with coronavirus disease 2019 (COVID-19).
... BACKGROUND: Very little direct evidence exists on use of corticosteroids in patients with coronavirus disease 2019 (COVID-19). Indirect evidence from related conditions must therefore inform inferences regarding benefits and harms. To support a guideline for managing COVID-19, we conducted systematic reviews examining the impact of corticosteroids ...
Ref: cord_uid r8rd5f2j Efficacy and safety of corticosteroids in COVI... r8rd5f2j Efficacy and safety of corticosteroids in COVI... Name: title, dtype: object [Virus Res, cord_uid r8rd5f2j 2020 r8rd5f2j 2020 Name: publish_time, dtype: object]The emergence of novel Coronavirus 2019 and the subsequent pandemic are presenting a challenge to neurologists managing patients with multiple sclerosis (MS).
... The emergence of novel Coronavirus 2019 and the subsequent pandemic are presenting a challenge to neurologists managing patients with multiple sclerosis (MS). The clinical management has dramatically altered and it was necessary to change and/or adapt it to the new situation. Regarding relapses management, the use of intravenous corticosteroids and hospitalization during ...
Ref: Would it be recommended treating multiple sclerosis relapses with high dose oral instead intravenous steroids during the COVID-19 pandemic? Yes [Mult Scler Relat Disord, 2020]Corticosteroids have anti-inflammatory effects and can improve lung injury and reduce mortality in ARDS [88] .
... Corticosteroids have anti-inflammatory effects and can improve lung injury and reduce mortality in ARDS [88] . The three coronaviruses can cause patients to develop ARDS and the body produced a large number of inflammatory factors. Thus, immune regulation of corticosteroids may be suitable for the treatment ...
Ref: A comparative overview of COVID-19, MERS and SARS: Review article [Int J Surg, 2020-07-26]The use of intravenous corticosteroids constitutes the mainstay therapy for children with ASC.
... The use of intravenous corticosteroids constitutes the mainstay therapy for children with ASC. More than 70% respond to daily methylprednisolone according to the "Outcome of Steroid therapy in Colitis Individuals" study published by Turner et al in 2010. 13 We considered it appropriate ...
Ref: Adaptations to the current ECCO/ESPGHAN guidelines on the management of paediatric acute severe colitis in the context of the COVID-19 pandemic: a RAND appropriateness panel [Gut, 2020-09-01]Steroids may play a critical role in the current pandemic of coronavirus disease-2019 (COVID-19),
... Steroids may play a critical role in the current pandemic of coronavirus disease-2019 (COVID-19), given the dearth of specific therapeutic options. This review was conducted to evaluate the impact of glucocorticoid therapy in patients with COVID-19 based on the publications reported to date. A ...
Ref: Are the steroids a blanket solution for COVID-19? A systematic review and meta-analysis [J. med. virol, 2020]Prednisolone is immunosuppressive in a dosage ≥10 mg per day or a total cumulative dose ≥700mg.
... • Patients on corticosteroids for treatment of leprosy reactions and nerve function impairment: Prednisolone is immunosuppressive in a dosage ≥10 mg per day or a total cumulative dose ≥700mg. Consequently, considering that most patients in leprosy reactions require long periods of treatment with varying doses of ...
Ref: Management of Leprosy in the Context of COVID-19 Pandemic: Recommendations by SIG Leprosy (IADVL Academy) [Indian Dermatol Online J, 2020-05-10]Corticosteroids dampen cytokine responses and the recruitment of leukocytes, and suppress T cell activation and differentiation 18 ;
... Corticosteroids dampen cytokine responses and the recruitment of leukocytes, and suppress T cell activation and differentiation 18 ; for these reasons, they can increase the risk of infection as a result of short-term lymphopenia 19 . However, short-term therapy is not usually associated with a marked increase in ...
Ref: Neurological immunotherapy in the era of COVID-19 — looking for consensus in the literature [Nat Rev Neurol, 2020-07-08]recognizing that these are commonly used treatments in the field of headache medicine.
... literature on non-steroidal anti-inflammatory drug and corticosteroid use during the coronavirus disease 2019 (COVID-19) pandemic, recognizing that these are commonly used treatments in the field of headache medicine. BACKGROUND: The use of non-steroidal anti-inflammatory drugs and corticosteroids in patients during the COVID-19 pandemic ...
Ref: COVID-19 and Headache Medicine: A Narrative Review of Non-Steroidal Anti-Inflammatory Drug (NSAID) and Corticosteroid Use [Headache, 2020]We found a significant clinical and biochemical association between corticosteroids and improved surrogate outcomes in late-onset CRS associated with COVID-19.
... who presented with progressive respiratory failure along with progressive inflammatory biomarkers consistent with severe CRS. We found a significant clinical and biochemical association between corticosteroids and improved surrogate outcomes in late-onset CRS associated with COVID-19. Corticosteroids are indicated to treat CRS occurring from immune or chimeric antigen receptor therapy, but ...
Ref: Corticosteroids for critically ill COVID-19 patients with cytokine release syndrome: a limited case series [Can J Anaesth, 2020-05-11]The administration of corticosteroids in the treatment of viral pneumonia is controversial.
... The administration of corticosteroids in the treatment of viral pneumonia is controversial. Although, some western scholars 9 have suggested that there are no clinical data to indicate that a net benefit is derived from corticosteroids in the treatment of respiratory infection due ...
Ref: Duration of SARS‐CoV‐2 RNA shedding and factors associated with prolonged viral shedding in patients with COVID‐19 [J Med Virol, 2020-07-09]Patients who received systematic corticosteroids showed a significant decrease in CK concentration.
... infection in rhesus macaques [15] and hand, foot, and mouth disease in humans [16] . Patients who received systematic corticosteroids showed a significant decrease in CK concentration. Elevated CK is present in the serum when there is cell injury, fever, and stress ...
Ref: cord_uid mq9vjnro Clinical characteristics and drug therapies in... mq9vjnro Clinical characteristics and drug therapies in... Name: title, dtype: object [J Med Virol, cord_uid mq9vjnro 2020-05-14 mq9vjnro 2020-05-14 Name: publish_time, dtype: object]The effects of high-dose corticosteroids on immune function are pleiotropic;
... Cunningham virus, and hepatitis B, may be increased with a number of agents (9) . The effects of high-dose corticosteroids on immune function are pleiotropic; however, their effect on macrophage production of IL-1, IL-6, and tumor necrosis factor may be ...
Ref: Considerations for the Treatment of Inflammatory Neuro-Ophthalmologic Disorders During the COVID-19 Pandemic [J Neuroophthalmol, 2020-06-23]Concurrent treatment with immunosuppressants, including corticosteroids,
... BACKGROUND Autoimmune pancreatitis (AIP) is a rare, steroid-responsive disease of the pancreas. Concurrent treatment with immunosuppressants, including corticosteroids, increases the risk of developing a severe form of coronavirus disease 2019 (COVID-19) due to infection with severe ...
Ref: High-Dose Prednisone for Treatment of Autoimmune Pancreatitis in a Patient with Coronavirus Disease 2019 (COVID-19) due to Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) [Am J Case Rep, 2020]Corticosteroids have been the cornerstone in managing hyper-inflammatory disorders due to their broad effects leading to reduced inflammatory mediators and immune cell activity.
... Corticosteroids have been the cornerstone in managing hyper-inflammatory disorders due to their broad effects leading to reduced inflammatory mediators and immune cell activity. Used alone or in combination with cytotoxic therapies, responses are frequent but often short-lived and associated with significant long-term toxicity. The HLH-94 protocol combines upfront dexamethasone with etoposide for its ...
Ref: Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes [Blood Rev, 2020-05-15]The use of corticosteroids in COVID-19 remains a major controversy.
... China, has rapidly spread around the world with high mortality rate among critically ill patients. The use of corticosteroids in COVID-19 remains a major controversy. Available evidences are inconclusive. According to WHO guidance, corticosteroids are not recommended to be used ...
Ref: Corticosteroid treatment in severe COVID-19 pneumonia: two cases and literature review [Clin Rheumatol, 2020]One of these treatments, dexamethasone, has already demonstrated a mortality benefit in a large randomized controlled trial [4] .
... and treatment of this phenotype have focused on medications with antiviral, antithrombotic, and/or anti-inflammatory properties. One of these treatments, dexamethasone, has already demonstrated a mortality benefit in a large randomized controlled trial [4] . Analogies with cytokine storm, which may or may not be an apt comparison [5] , ...
Ref: Tocilizumab versus the covid19 tempest: all’s well that ends well or much ado about nothing? [Clin Microbiol Infect, 2020-09-29]In COVID-19, persistent viral load contributes to the development of T cell abnormalities and cytokine release syndrome.
... monitoring of the patient in terms of hyperglycemia, hypernatremia, and hypokalemia is required [38] . In COVID-19, persistent viral load contributes to the development of T cell abnormalities and cytokine release syndrome. A significant increase in cytokines such as TNF-α, IL-1β, IL-6 and IL-10, as well as ...
Ref: Coronavirus disease 2019 (COVID-19) in a patient with ankylosing spondylitis treated with secukinumab: a case-based review [Rheumatol Int, 2020-06-26]corticosteroids have shown preliminary evidence of benefit, they can act like a double-edged sword for majority of COVID-19 patients.
... of COVID-19. Immune-mediated inflammation remains the hallmark of severe complications related to COVID-19 and while corticosteroids have shown preliminary evidence of benefit, they can act like a double-edged sword for majority of COVID-19 patients. Therefore, there is a need to identify ‘non-steroid’ potent and safe anti-inflammatory agents for use ...
Ref: Can roflumilast become steroid-sparing alternative in the treatment of COVID-19? [Med. Hypotheses, 2020]Therapeutic options such as steroids are in need of further elucidation for COVID-19-induced lung injuries.
... on the problems of widespread ineffective antiviral use by physicians for management of the patients. Therapeutic options such as steroids are in need of further elucidation for COVID-19-induced lung injuries. Additionally, the evidence for potential harm or benefit (i.e., safety and efficacy) of azithromycin and ...
Ref: The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study [Daru, 2020-06-19]steroids, usually methylprednisolone, are currently administered despite data on effects and lethality are contradictory.
... In critically ill patients affected by severe acute respiratory syndrome caused by Sars-Cov-2 infection, steroids, usually methylprednisolone, are currently administered despite data on effects and lethality are contradictory. On the other hand, steroids treatment can cause symptoms of hypercortisolism, especially in patients with individual ...
Ref: COVID-19 outbreak and steroids administration: are patients treated for Sars-Cov-2 at risk of adrenal insufficiency? [J Endocrinol Invest, 2020-04-16]Professional societies continue to support the use of antenatal corticosteroids when indicated for lung maturation among women with COVID-19 10, 12-18 .
... Professional societies continue to support the use of antenatal corticosteroids when indicated for lung maturation among women with COVID-19 10, 12-18 . However, risks and benefits of corticosteroids should be carefully weighed for women with critical illness, and their administration should not delay urgent delivery 15, 16 . Given the lack of ...
Ref: Pregnancy and COVID‐19: Pharmacologic Considerations [Ultrasound Obstet Gynecol, 2020-09-21]Corticosteroids can be categorized into the mineralocorticoids and the glucocorticoids.
... Corticosteroids can be categorized into the mineralocorticoids and the glucocorticoids. The mineralocorticoids, which mimic the actions of aldosterone, affect kidney function by increasing the Na + and H2O reabsorption. Because this mechanism does not promote Ang II formation, it is ...
Ref: Anti-Inflammatory Drugs and the Renin-Angiotensin-Aldosterone System: Current Knowledge and Potential Effects on Early SARS-CoV-2 Infection [Virus Res, 2020-10-08]Corticosteroids can diminish this damage by reducing inflammatory cytokines like IL-1 and IL-6.
... receptors like the lung. This damage causes ARDS that is the main cause of death. Corticosteroids can diminish this damage by reducing inflammatory cytokines like IL-1 and IL-6. They also increase the production of IL-10, an anti-inflammatory mediator. It is claimed that using ...
Ref: Classification of the present pharmaceutical agents based on the possible effective mechanism on the COVID-19 infection [Daru, 2020-07-30]This study aimed to observe the efficacy of corticosteroids in non-severe COVID-19 pneumonia.
... OBJECTIVES: This study aimed to observe the efficacy of corticosteroids in non-severe COVID-19 pneumonia. METHODS: A retrospective study based on propensity score matching was designed to explore the effects of corticosteroids. Primary outcomes included the rate of patients who developed severe disease and ...
Ref: Efficacy Evaluation of Early, Low-Dose, Short-Term Corticosteroids in Adults Hospitalized with Non-Severe COVID-19 Pneumonia: A Retrospective Cohort Study [Daru, 2020]The corticosteroids (inhaled and oral) are commonly prescribed in the management of asthma and COPD patients
... among public and healthcare professionals regarding the safety of steroid use during the SARS-CoV-2 pandemic. The corticosteroids (inhaled and oral) are commonly prescribed in the management of asthma and COPD patients and any unsolicited changes in medications use may lead to potentially severe exacerbations and risk ...
Ref: Use of corticosteroids in asthma and COPD patients with or without COVID-19 [Respir Med, 2020-05-26]BACKGROUND Treatment with corticosteroids for COVID-19 and ARDS (acute respiratory distress syndrome) is controversial and has generally not been recommended.
... BACKGROUND Treatment with corticosteroids for COVID-19 and ARDS (acute respiratory distress syndrome) is controversial and has generally not been recommended. CASE PRESENTATION A woman in her sixties was admitted to hospital after ten days of flu-like symptoms. She was confirmed as Sars-CoV-2-positive and experienced a steady decrease in oxygen saturation ...
Ref: Patient with severe COVID-19 treated with corticosteroids. [Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2020-09-08]Antenatal corticosteroids given prior to preterm deliveries reduce the risk of adverse neonatal outcomes.
... OBJECTIVE: Antenatal corticosteroids given prior to preterm deliveries reduce the risk of adverse neonatal outcomes. However, steroid administration in the setting of a viral respiratory infection can worsen maternal outcomes. Therefore, the decision to administer corticosteroids must balance the neonatal benefits with the potential ...
Ref: Antenatal Corticosteroids for Pregnant Women at High Risk of Preterm Delivery with COVID-19 Infection: A Decision Analysis [Am J Perinatol, 2020]During the SARS-CoV epidemic of 2003, therapeutic systemic corticosteroids were administered in patients who were infected and developed severe respiratory disease.
... During the SARS-CoV epidemic of 2003, therapeutic systemic corticosteroids were administered in patients who were infected and developed severe respiratory disease. In a meta-analysis of corticosteroid use in patients with SARS, only four studies provided conclusive data, all indicating higher mortality (6). One recent systematic review and meta-analysis identified ten observational ...
Ref: Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature [Front Med (Lausanne), 2020-04-24]Oral steroids were used by 15 out of 220 asthma patients:
... (2) using ICS alone or (3) using ICS/LABA at the time of COVID-19 577 diagnosis. Oral steroids were used by 15 out of 220 asthma patients: outpatient (N=7), 578 inpatient -no ICU (N=8) and inpatient -ICU (N=0). Bars represent mean ± ...
Ref: Prevalence and characterization of asthma in hospitalized and non-hospitalized patients with COVID-19 [J Allergy Clin Immunol, 2020-06-15]Corticosteroids are commonly used as adjuvant therapy for acute respiratory distress syndrome (ARDS) by many clinicians due to their perceived anti-inflammatory effects.
... BACKGROUND: Corticosteroids are commonly used as adjuvant therapy for acute respiratory distress syndrome (ARDS) by many clinicians due to their perceived anti-inflammatory effects. However, for patients with severe viral pneumonia, the corticosteroid treatment is highly controversial. OBJECTIVES: The purpose of this review is to systematically evaluate the effect and potential mechanism of ...
Ref: Corticosteroid administration for viral pneumonia: COVID-19 and beyond [Clin Microbiol Infect, 2020-06-27]patients treated with corticosteroids had delayed clinical healing (p = 0.013).
... (p = 0.035). Moreover, patients presenting at admission a lower PaO2/FiO2 ratio and more severe disease showed longer viral shedding (p = 0.031 and p = 0.032, respectively). In addition, patients treated with corticosteroids had delayed clinical healing (p = 0.013). ...
Ref: Duration of COVID-19: Data from an Italian Cohort and Potential Role for Steroids. [Microorganisms, 2020-08-31]She was treated with cyclosporine and steroids for ulcerative colitis, and azithromycin and hydroxychloroquine for Covid-19.
... colitis during her first trimester of pregnancy who also had diagnosis of Covid-19 [19] . She was treated with cyclosporine and steroids for ulcerative colitis, and azithromycin and hydroxychloroquine for Covid-19. Unfortunately, the patient experienced a spontaneous abortion. Mazza S et al, described a case of ...
Ref: COVID-19 IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW OF CLINICAL DATA [Dig Liver Dis, 2020-09-06]corticosteroid use has been the subject of debate.
... Background: Since the start of the novel coronavirus 2019 (COVID-19) pandemic, corticosteroid use has been the subject of debate. The available evidence is uncertain, and knowledge on the subject is evolving. The aim of our cohort study was ...
Ref: Effect of corticosteroid treatment on 1376 hospitalized COVID-19 patients. A cohort study. [Dig Liver Dis, 2020-07-18]Intravenous corticosteroids remain the most widely used induction therapy in ASUC,
... risk of the drugs used to manage ASUC in the context of the COVID-19 pandemic. Intravenous corticosteroids remain the most widely used induction therapy in ASUC, 25 but it is uncertain how they may influence outcome in patients with SARS-CoV-2 infection ...
Ref: Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic: a RAND appropriateness panel [Gut, 2020-06-08]The role of corticosteroids in children with COVID-19 or MIS-C has yet to be fully elucidated.
... as against use in mechanically ventilated patients without ARDS. For patients that are mechanically ventilated with ARDS, NIH states that there is insufficient evidence for or against use of corticosteroids. The role of corticosteroids in children with COVID-19 or MIS-C has yet to be fully elucidated. ...
Ref: Hyperinflammation and the utility of immunomodulatory medications in children with COVID-19 [Paediatr Respir Rev, 2020-07-29]Corticosteroid therapy was empirically used for clinical treatment in the early stage of the disease outbreak;
... by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that was identified in December 2019 Corticosteroid therapy was empirically used for clinical treatment in the early stage of the disease outbreak; however, data regarding its efficacy and safety are controversial The aim of this study was ...
Ref: Efficacy and Safety of Corticosteroid Treatment in Patients With COVID-19: A Systematic Review and Meta-Analysis [Frontiers in Pharmacology, 2020]Corticosteroids may diminish the inflammatory response, a major factor for lung damage and acute respiratory distress syndrome in viral respiratory tract infection.
... the usefulness and safety of corticosteroids as an adjuvant therapy for COVID-19 pneumonia remains controversial. Corticosteroids may diminish the inflammatory response, a major factor for lung damage and acute respiratory distress syndrome in viral respiratory tract infection. However, previous studies on corticosteroid therapy in severe acute respiratory syndrome coronavirus and Middle East ...
Ref: Antenatal corticosteroid therapy and COVID‐19: Pathophysiological considerations [Acta Obstet Gynecol Scand, 2020-05-17]the headache medicine clinician must consider any risks related to the use of NSAIDs and corticosteroids for headache and weigh them against the potential benefits.
... [9] [10] [11] [12] Given that all patients are at risk of potentially contracting COVID-19, the headache medicine clinician must consider any risks related to the use of NSAIDs and corticosteroids for headache and weigh them against the potential benefits. We have gathered and summarized the most current literature on the use of NSAIDs and ...
Ref: COVID‐19 and Headache Medicine: A Narrative Review of Non‐Steroidal Anti‐Inflammatory Drug (NSAID) and Corticosteroid Use [Headache, 2020-07-10]